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突破微创手术的界限:完全腹腔镜下左肝切除术扩展至肝段8用于双叶结直肠癌肝转移

Pushing the Boundaries of Minimally Invasive Surgery: Fully Laparoscopic Left Hepatectomy Extended to Segment 8 for Bilobar Colorectal Liver Metastases.

作者信息

Sotomayor Ledezma Camila, Reyes Natalia, Soto Pedro, Briceño Eduardo, Dib Martín, Viñuela Eduardo, Martínez Jorge, Jarufe Nicolás

机构信息

Department of Hepatobiliary and Pancreatic Surgery, Pontificia Universidad Católica de Chile, Santiago, CHL.

Department of Surgery, Hospital Clínico Dra. Eloísa Díaz I. La Florida, Santiago, CHL.

出版信息

Cureus. 2024 Nov 27;16(11):e74557. doi: 10.7759/cureus.74557. eCollection 2024 Nov.

DOI:10.7759/cureus.74557
PMID:39735101
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11680491/
Abstract

The surgical management of hepatic metastases from colorectal cancer may range from segmental resections to major or extended hepatectomies. The aim is to achieve complete removal of metastatic lesions while preserving adequate liver function. We present the case of a 42-year-old male patient with a history of glucose intolerance who presented with altered bowel movements and abdominal pain. After further evaluation, he was diagnosed with stage IV rectosigmoid cancer with potentially resectable bilobar liver metastases in segments 2, 4a-8, and 6. KRAS, NRAS, and BRAF were wild-type, and no microsatellite instability was detected. The patient underwent six cycles of chemotherapy with FOLFOX (oxaliplatin in combination with 5-fluorouracil and leucovorin), and radiofrequency ablation (RFA) was applied to the lesion in segment VI, resulting in a favorable response in imaging control. Consequently, we perform a laparoscopic extended left hepatectomy with wedge resection of the segment VI lesions previously treated with RFA. The video shows a completely laparoscopic left hepatectomy extended to segments 5 and 8 and also a resection of S6 metastasis. It is possible to appreciate the management of the left hepatic pedicle and the transection of the parenchyma with the use of energy instruments: cavitron ultrasonic surgical aspirator and bipolar. In addition to the dissection and section of the middle and left hepatic vein included in the surgical specimen. The patient experienced a rapid postoperative recovery with good liver function, an early hospital discharge, and a quick return to work, highlighting the clear advantages of laparoscopic surgery.

摘要

结直肠癌肝转移的外科治疗范围可从节段性切除到大型或扩大肝切除术。目的是在保留足够肝功能的同时完全切除转移灶。我们报告一例42岁男性患者,有糖耐量异常病史,出现排便习惯改变和腹痛。进一步评估后,他被诊断为IV期直肠乙状结肠癌,伴有2、4a - 8和6段潜在可切除的双叶肝转移。KRAS、NRAS和BRAF为野生型,未检测到微卫星不稳定。患者接受了六个周期的FOLFOX(奥沙利铂联合5-氟尿嘧啶和亚叶酸钙)化疗,并对VI段病灶进行了射频消融(RFA),影像学检查显示效果良好。因此,我们进行了腹腔镜扩大左肝切除术,楔形切除先前接受过RFA治疗的VI段病灶。视频展示了完全腹腔镜下扩大至5段和8段的左肝切除术以及S6转移灶的切除。可以看到使用能量器械(超声刀和双极电凝)处理左肝蒂和实质横断的过程。此外,手术标本还包括中肝静脉和左肝静脉的解剖与切断。患者术后恢复迅速,肝功能良好,早期出院并很快重返工作岗位,突出了腹腔镜手术的明显优势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f4f/11680491/a894bb8c9226/cureus-0016-00000074557-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f4f/11680491/6ab3b53956a1/cureus-0016-00000074557-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f4f/11680491/bb56329cee0a/cureus-0016-00000074557-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f4f/11680491/b76e375bafc4/cureus-0016-00000074557-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f4f/11680491/2a8c5c5b62d9/cureus-0016-00000074557-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f4f/11680491/beb6f3d505fb/cureus-0016-00000074557-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f4f/11680491/a894bb8c9226/cureus-0016-00000074557-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f4f/11680491/6ab3b53956a1/cureus-0016-00000074557-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f4f/11680491/bb56329cee0a/cureus-0016-00000074557-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f4f/11680491/b76e375bafc4/cureus-0016-00000074557-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f4f/11680491/2a8c5c5b62d9/cureus-0016-00000074557-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f4f/11680491/beb6f3d505fb/cureus-0016-00000074557-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f4f/11680491/a894bb8c9226/cureus-0016-00000074557-i06.jpg

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Surg Endosc. 2024 Aug;38(8):4583-4593. doi: 10.1007/s00464-024-11002-7. Epub 2024 Jul 1.
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Laparoscopic Versus Open Hemihepatectomy: The ORANGE II PLUS Multicenter Randomized Controlled Trial.腹腔镜与开腹半肝切除术的比较:ORANGE II PLUS 多中心随机对照试验。
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Evolution of laparoscopic liver resection in the last two decades: lessons from 2000 cases at a referral Korean center.过去二十年腹腔镜肝切除术的发展:来自韩国一家转诊中心2000例病例的经验教训。
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