Choi Joongwon, Yang Yun-Jung, Lee Chung Un, Kim Jung Hoon, Kim Jin Wook, Tae Jong Hyun, Choi Se Young, Chang In Ho, Yang Eun-Jung, Lee Yong Seong
Department of Urology, Chung-Ang University Gwangmyeong Hospital, Chung-Ang University College of Medicine, Gwangmyeong, Korea.
Department of Convergence Science, College of Medicine, Catholic Kwandong University International St. Mary's Hospital, Incheon, Korea.
Prostate Int. 2024 Dec;12(4):179-185. doi: 10.1016/j.prnil.2024.04.004. Epub 2024 Apr 29.
Restoration of postoperative urinary continence after robot-assisted radical prostatectomy (RARP) is affected by diverse factors. We compared the pad-free and positive margin rates of patients who underwent RARP with or without bladder neck sparing (BNS) for prostate cancer. During this systematic review and metaanalysis, we performed an electronic search of the Web of Science, Embase, Cochrane Central Register of Controlled Trials, and PubMed to find original articles comparing RARP with and without BNS for prostate cancer. We identified six studies (2,351 patients in total) who underwent RARP with or without BNS. A metaanalysis of the pad-free rate at 3 months was performed. The overall pad-free rate at 3 months for patients who underwent RARP with BNS was significantly higher than that of patients who underwent RARP alone (control group) (odds ratio, 1.86; 95% confidence interval [CI], 1.22-2.82), with high heterogeneity ( = 0.005; I = 67.45%). The pad-free rates at 7 days, 6 months, and 1 year and positive surgical margin rates of patients who underwent BNS were not significantly different than those in the control group. Although no statistical difference was observed, the catheterization period of the BNS group was shorter than that of the control group (standardized mean difference = -0.08; 95% CI, -0.16 to 0.01). Although RARP with BNS did not affect the long-term outcome of continence, it had a significant effect on the early recovery of continence.
机器人辅助根治性前列腺切除术(RARP)后术后尿失禁的恢复受多种因素影响。我们比较了接受或未接受保留膀胱颈(BNS)的前列腺癌患者在RARP术后的无尿垫率和切缘阳性率。在这项系统评价和荟萃分析中,我们对科学网、Embase、Cochrane对照试验中央注册库和PubMed进行了电子检索,以查找比较有或无BNS的前列腺癌患者接受RARP的原始文章。我们确定了6项研究(共2351例患者),这些患者接受了有或无BNS的RARP。对3个月时的无尿垫率进行了荟萃分析。接受BNS的RARP患者在3个月时的总体无尿垫率显著高于单纯接受RARP的患者(对照组)(优势比,1.86;95%置信区间[CI],1.22 - 2.82),异质性较高( = 0.005;I = 67.45%)。接受BNS的患者在7天、6个月和1年时的无尿垫率以及手术切缘阳性率与对照组无显著差异。尽管未观察到统计学差异,但BNS组的导尿期比对照组短(标准化均值差 = -0.08;95% CI,-0.16至0.01)。虽然有BNS的RARP不影响尿失禁的长期结果,但它对尿失禁的早期恢复有显著影响。