Lachinova Daria A, Smirnova Maria P, Pavlova Irina V, Sysoev Ilya V, Vinogradova Lyudmila V
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia.
Saratov State University, Saratov, Russia.
Netw Neurosci. 2024 Dec 10;8(4):1383-1399. doi: 10.1162/netn_a_00405. eCollection 2024.
Cortical spreading depolarization (CSD), a slowly propagating wave of transient cellular depolarization, is a reliable cortical response to various brain insults (stroke, trauma, seizures) and underlying mechanism of migraine aura. Little is known about CSD effects on brain network activity. Using undirected (mutual information, MI) and directed (transfer entropy, TE) measures, we studied the dynamics of cross-hemispheric connectivity associated with the development of unilateral CSD in freely behaving rats and the involvement of inhibitory transmission in mechanisms of the coupling changes. We show that the development of CSD in the cortex of one hemisphere is followed by the transient loss of undirected functional connectivity (MI) between ipsilateral and contralateral cortical regions. The post-CSD functional disconnection of the hemispheres was accompanied by an increase in driving force from an unaffected contralateral cortex to an affected one (TE). Mild cortical disinhibition produced by pretreatment with an inhibitory receptor blocking agent (penthylenetetrazole) did not affect CSD but attenuated (MI) or eliminated (TE) the CSD-induced connectivity changes. The effects of CSD on functional connectivity in awake rodents were similar at the individual and group levels, suggesting that the described connectivity response may be a promising network biomarker of CSD occurrence in patients.
皮层扩散性去极化（CSD）是一种缓慢传播的瞬时细胞去极化波，是对各种脑损伤（中风、创伤、癫痫）的可靠皮层反应，也是偏头痛先兆的潜在机制。关于CSD对脑网络活动的影响知之甚少。我们使用无向（互信息，MI）和有向（转移熵，TE）测量方法，研究了自由活动大鼠单侧CSD发展过程中跨半球连接的动态变化以及抑制性传递在耦合变化机制中的作用。我们发现，一个半球皮层中CSD的发展伴随着同侧和对侧皮层区域之间无向功能连接（MI）的短暂丧失。CSD后半球的功能断开伴随着从未受影响的对侧皮层到受影响皮层的驱动力增加（TE）。用抑制性受体阻断剂（戊四氮）预处理产生的轻度皮层去抑制并不影响CSD，但减弱了（MI）或消除了（TE）CSD诱导的连接变化。CSD对清醒啮齿动物功能连接的影响在个体和群体水平上相似，这表明所描述的连接反应可能是患者CSD发生的一个有前景的网络生物标志物。
