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一名患有费城染色体阳性急性淋巴细胞白血病的年轻成年患者，表现为极度白细胞增多症。

A young adult patient with Philadelphia positive acute lymphoblastic leukemia presenting with extreme hyperleukocytosis.

作者信息

Tikit Gulten, Yucesu Elif, Sarıfakıoglu Aliye Serpil, Dilek Imdat, Bakanay Sule Mine

机构信息

Department of Hematology, Ankara Yıldırım Beyazıt University Faculty of Medicine Ankara Bilkent City Hospital Ankara Turkey.

Ankara Bilkent City Hospital Hematology Clinics Ankara Turkey.

出版信息

Clin Case Rep. 2024 Dec 26;13(1):e9512. doi: 10.1002/ccr3.9512. eCollection 2025 Jan.

DOI:10.1002/ccr3.9512
PMID:39735791
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11671230/
Abstract

Extreme hyperleukocytosis (Leukocyte count >200 × 10/L) in an adolescent young adult (AYA) patient with B-ALL could result in mild symptoms of leukostasis. Hyperleukocytosis requires prompt initiation of therapy with adequate hydration, cytoreduction and prevention of tumor lysis. Ph + B-ALL may present with extreme hyperleukocytosis and may be resistant to initial pre-phase therapy. In such cases, leukocytapheresis is beneficial in reducing the leukocyte count as well as controlling the symptoms.

摘要

一名患有B-ALL的青少年及年轻成人（AYA）患者出现极度白细胞增多症（白细胞计数>200×10⁹/L）可能会导致轻度白细胞淤滞症状。白细胞增多症需要迅速开始治疗，包括充分补液、细胞数量减少和预防肿瘤溶解。Ph+ B-ALL可能表现为极度白细胞增多症，并且可能对初始诱导缓解期治疗耐药。在这种情况下，白细胞单采术有助于降低白细胞计数并控制症状。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a51a/11671230/f5794bda0d48/CCR3-13-e9512-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a51a/11671230/1d061f436fbf/CCR3-13-e9512-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a51a/11671230/f5794bda0d48/CCR3-13-e9512-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a51a/11671230/1d061f436fbf/CCR3-13-e9512-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a51a/11671230/f5794bda0d48/CCR3-13-e9512-g001.jpg

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