Tang Jiajia, Shi Jun, Han Zhihai, Chen Xuxin
Department of Pulmonary and Critical Care Medicine, The Sixth Medical Center of Chinese PLA General Hospital, 100048 Beijing, China.
School of Medicine, South China University of Technology, 510006 Guangzhou, Guangdong, China.
Front Biosci (Landmark Ed). 2024 Dec 6;29(12):412. doi: 10.31083/j.fbl2912412.
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common critical illness. Supportive therapy is still the main strategy for ALI/ARDS. Macrophages are the predominant immune cells in the lungs and play a pivotal role in maintaining homeostasis, regulating metabolism, and facilitating tissue repair. During ALI/ARDS, these versatile cells undergo polarization into distinct subtypes with significant variations in transcriptional profiles, developmental trajectory, phenotype, and functionality. This review discusses developments in the analysis of alveolar macrophage subtypes in the study of ALI/ARDS, and the potential value of targeting new macrophage subtypes in the diagnosis, prognostic evaluation, and treatment of ALI/ARDS.
急性肺损伤（ALI）/急性呼吸窘迫综合征（ARDS）是一种常见的危重病。支持性治疗仍然是ALI/ARDS的主要治疗策略。巨噬细胞是肺内主要的免疫细胞，在维持内环境稳定、调节代谢和促进组织修复方面发挥着关键作用。在ALI/ARDS期间，这些多功能细胞会极化为不同的亚型，其转录谱、发育轨迹、表型和功能存在显著差异。本文综述了ALI/ARDS研究中肺泡巨噬细胞亚型分析的进展，以及靶向新的巨噬细胞亚型在ALI/ARDS诊断、预后评估和治疗中的潜在价值。
