Zhao Zherui, Shi Wanting, Wu Yufei, Kong Linxiu, Gao Jun, Kong Yong
Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China.
Hua Lookeng Honors College, Changzhou University, Changzhou 213164, China.
Int J Biol Macromol. 2025 Mar;292:139196. doi: 10.1016/j.ijbiomac.2024.139196. Epub 2024 Dec 28.
A stimuli-responsive drug delivery system is developed for controlled delivery of curcumin (Cur) and chemo-photothermal therapy of breast cancer (BC). Cur is first loaded into mesoporous polydopamine nanoparticles (mPDA NPs) by π-π stacking, and then the Cur loaded mPDA NPs (mPDA NPs@Cur) are encapsulated in the hydrogels prepared through the crosslinking of oxidized konjac glucomannan (oxKGM) and carboxymethyl chitosan (CMCS). Owing to the pH-sensitivity of the hydrogels and the outstanding photothermal conversion capability of mPDA NPs, the release of Cur from the hydrogels can be greatly accelerated in acidic media upon near infrared (NIR) irradiation. Cytotoxicity assay indicates that the hydrogels have significant cytotoxicity against murine breast tumor cell 4 T1 while the drug-free hydrogels (oxKGM/CMCS/mPDA NPs) show good biocompatibility. In addition, the hyperthermia generated upon NIR irradiation can lead to the apoptosis of cancer cells, achieving chemo-photothermal combination therapy of BC. Release kinetics study reveals that the release of Cur from the hydrogels follows zero-order model.
开发了一种刺激响应型药物递送系统，用于姜黄素（Cur）的控释及乳腺癌（BC）的化学-光热治疗。首先通过π-π堆积将Cur负载到介孔聚多巴胺纳米颗粒（mPDA NPs）中，然后将负载Cur的mPDA NPs（mPDA NPs@Cur）封装在通过氧化魔芋葡甘聚糖（oxKGM）和羧甲基壳聚糖（CMCS）交联制备的水凝胶中。由于水凝胶的pH敏感性和mPDA NPs出色的光热转换能力，在近红外（NIR）照射下，Cur从水凝胶中的释放在酸性介质中可大大加速。细胞毒性试验表明，水凝胶对小鼠乳腺肿瘤细胞4T1具有显著的细胞毒性，而不含药物的水凝胶（oxKGM/CMCS/mPDA NPs）具有良好的生物相容性。此外，NIR照射产生的热疗可导致癌细胞凋亡，实现BC的化学-光热联合治疗。释放动力学研究表明，Cur从水凝胶中的释放遵循零级模型。
