埃及患者中过敏性鼻炎与自身免疫性甲状腺疾病发生之间的关联。

Association between allergic rhinitis and development of autoimmune thyroid diseases in Egyptian patients.

作者信息

Allam Magdy Mohamed, Ahmed Soha Magdy, El-Deeb Dalia Khamis, Bahgat Ahmed Yassin, Ghazy Ramy Mohamed, El-Zawawy Hanaa Tarek

机构信息

Internal Medicine Department, Endocrinology Division, Alexandria University Student Hospital (AUSH), Alexandria University, Alexandria, Egypt.

Internal Medicine Department, Alexandria University Student Hospital (AUSH), Alexandria University, Alexandria, Egypt.

出版信息

BMC Endocr Disord. 2024 Dec 31;24(1):202. doi: 10.1186/s12902-024-01685-3.

DOI:10.1186/s12902-024-01685-3

PMID:39736641

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11687071/

Abstract

BACKGROUND

Autoimmune thyroid diseases (AITD) and allergic rhinitis (AR) are prevalent conditions; however, limited research has investigated their association. This study aimed to evaluate whether AR can be considered a risk factor for developing AITD.

METHODS

A retrospective cohort study analyzed the records of AITD patients who visited Alexandria University Students Hospital between January 2017 and December 2021. The parameters included in the study were thyroid-stimulating hormone (TSH), Free triiodothyronine (FT3), free thyroxine (FT4), thyroid peroxidase antibodies (TPOAb), thyrotropin receptor antibody (TRAb), eosinophils count, and IgE.

RESULTS

Out of 4,515 eligible patients, 41.7% were diagnosed with AR in addition to AITD. Among the patients with both conditions, 81% were females, their mean age was 45.71 ± 24.14 years, and the mean duration of AITD was 7.32 ± 2.11 years. The Kaplan-Meier analysis revealed that the AR cohort had a higher cumulative incidence of AITD than did the non-AR cohort (log-rank test, p = 0.001). Multivariate-adjusted hazardous ratios showed that patients with AR, female sex, higher white blood cell count, and diagnosis in November had a higher risk of developing AITD.

CONCLUSIONS

Screening for AITD should be conducted at the time of diagnosis of AR as it could be a risk factor for AITD.

摘要

背景

自身免疫性甲状腺疾病（AITD）和变应性鼻炎（AR）是常见病症；然而，对它们之间关联的研究有限。本研究旨在评估AR是否可被视为发生AITD的危险因素。

方法

一项回顾性队列研究分析了2017年1月至2021年12月期间就诊于亚历山大大学学生医院的AITD患者的记录。研究纳入的参数包括促甲状腺激素（TSH）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、甲状腺过氧化物酶抗体（TPOAb）、促甲状腺激素受体抗体（TRAb）、嗜酸性粒细胞计数和IgE。

结果

在4515名符合条件的患者中，41.7%除患有AITD外还被诊断为AR。在同时患有这两种疾病的患者中，81%为女性，平均年龄为45.71±24.14岁，AITD的平均病程为7.32±2.11年。Kaplan-Meier分析显示，AR队列中AITD的累积发病率高于非AR队列（对数秩检验，p = 0.001）。多变量调整后的风险比显示，患有AR、女性、白细胞计数较高以及在11月确诊的患者发生AITD的风险更高。