Kuspinar Ayse, Na Eunjung, Hum Stanley, Jones Allyson, Mayo Nancy
School of Rehabilitation Science, Faculty of Health Sciences, McMaster University, 1400 Main St. W., IAHS, Hamilton, ON, Canada.
Centre for Outcomes Research and Evaluation, McGill University Health Centre-Research Institute, Montreal, QC, Canada.
Health Qual Life Outcomes. 2024 Dec 31;22(1):113. doi: 10.1186/s12955-024-02331-1.
Health-related quality of life (HRQL) is an important endpoint when evaluating the effectiveness of interventions in people living with hip and knee osteoarthritis (OA). The aim of this study was to generate domains for a new OA-specific preference-based index of HRQL in people living with hip or knee OA.
The proposed HRQL index was based on a formative measurement model. The study included people aged 50 years and older, who reported being diagnosed with hip or knee OA. Participants reported the most important areas of their lives affected by OA. BERTopic method was used for topic modeling as part of Natural Language Processing. Hierarchical topic modeling was applied to merge similar topics together.
A total of 102 people participated from across Canada. The participants had a mean age of 64.3 ± 7.6 years, and they reported having either knee (48.0%) or hip (16.7%) OA, or both (35.3%). Six major topics that affect the quality of life of people with OA emerged from the BERTopic analysis. Pain, going up and down stairs, walking, standing at home or work, sleep, and playing with grandchildren were the major concerns reported by people living with OA.
This study used natural language processing to generate domains for a new OA-specific HRQL index that is based on the views of people living with hip or knee OA. Six domains important to people living with OA formed the construct of HRQL. The next steps will be to create items based on the topics generated from this analysis and elicit people's preferences for the different items.
在评估髋膝关节骨关节炎（OA）患者干预措施的有效性时，健康相关生活质量（HRQL）是一个重要的终点指标。本研究的目的是为一种新的基于髋膝关节OA患者偏好的特定OA健康相关生活质量指数生成领域。
拟议的健康相关生活质量指数基于一个形成性测量模型。该研究纳入了50岁及以上且报告被诊断为髋或膝关节OA的人群。参与者报告了其生活中受OA影响最重要的领域。作为自然语言处理的一部分，使用BERTopic方法进行主题建模。应用层次主题建模将相似主题合并在一起。
共有来自加拿大各地的102人参与。参与者的平均年龄为64.3±7.6岁，他们报告患有膝关节OA（48.0%）、髋关节OA（16.7%）或两者都有（35.3%）。BERTopic分析得出了影响OA患者生活质量的六个主要主题。疼痛、上下楼梯、行走、在家或工作时站立、睡眠以及与孙辈玩耍是OA患者报告的主要担忧。
本研究使用自然语言处理为一种基于髋膝关节OA患者观点的新的特定OA健康相关生活质量指数生成领域。对OA患者重要的六个领域构成了健康相关生活质量的结构。下一步将根据该分析生成的主题创建条目，并引出人们对不同条目的偏好。
