Yan Cheng, Wu Haojie, Fang Xianchun, He Junji, Zhu Feng
Department of Blood Transfusion, Nanjing Jiangning Hospital, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Front Med (Lausanne). 2023 Mar 10;10:1074878. doi: 10.3389/fmed.2023.1074878. eCollection 2023.
Platelets, anucleate blood components, represent the major cell type involved in the regulation of hemostasis and thrombosis. In addition to performing haemostatic roles, platelets can influence both innate and adaptive immune responses. In this review, we summarize the development of platelets and their functions in hemostasis. We also discuss the interactions between platelet products and innate or adaptive immune cells, including neutrophils, monocytes, macrophages, T cells, B cells and dendritic cells. Activated platelets and released molecules regulate the differentiation and function of these cells platelet-derived receptors or secreting molecules. Platelets have dual effects on nearly all immune cells. Understanding the exact mechanisms underlying these effects will enable further application of platelet transfusion.
血小板是无核血细胞，是参与止血和血栓形成调节的主要细胞类型。除发挥止血作用外，血小板还可影响先天性和适应性免疫反应。在本综述中，我们总结了血小板的发育及其在止血中的功能。我们还讨论了血小板产物与先天性或适应性免疫细胞（包括中性粒细胞、单核细胞、巨噬细胞、T细胞、B细胞和树突状细胞）之间的相互作用。活化的血小板和释放的分子通过血小板衍生的受体或分泌分子调节这些细胞的分化和功能。血小板对几乎所有免疫细胞都有双重作用。了解这些作用背后的确切机制将有助于血小板输血的进一步应用。
