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肠道微生物群在憩室病发病机制中的作用:我们目前的研究进展如何?

The role of gut microbiota in the pathogenesis of diverticular disease: where are we now?

作者信息

Tursi Antonio, Papa Alfredo

机构信息

Territorial Gastroenterology Service, Barletta-Andria-Trani Local Health Agency, Via Torino, 49, Andria, BT, 76123, Italy.

Department of Medical and Surgical Sciences, School of Medicine, Catholic University, Rome, Italy.

出版信息

Genome Med. 2024 Dec 30;16(1):153. doi: 10.1186/s13073-024-01426-0.

DOI:10.1186/s13073-024-01426-0
PMID:39736798
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11686895/
Abstract

Diverticular disease (DD) is widespread worldwide. The role of gut microbiota (GM) in DD is not entirely understood.  Here we discuss the significance of the current knowledge on GM in the different stages of DD and how crucial these acquisitions are for designing diagnostic and therapeutic trials in this field.

摘要

憩室病(DD)在全球范围内广泛存在。肠道微生物群(GM)在憩室病中的作用尚未完全明确。在此,我们讨论当前关于肠道微生物群在憩室病不同阶段的知识的重要性,以及这些知识对于设计该领域的诊断和治疗试验的关键程度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e73/11686895/92bb31edafd5/13073_2024_1426_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e73/11686895/92bb31edafd5/13073_2024_1426_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e73/11686895/92bb31edafd5/13073_2024_1426_Fig1_HTML.jpg

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Eur J Gastroenterol Hepatol. 2025 Feb 1;37(2):147-153. doi: 10.1097/MEG.0000000000002884. Epub 2024 Nov 7.
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Gut microbiome structure and function in asymptomatic diverticulosis.无症状憩室病中的肠道微生物组结构和功能。
Genome Med. 2024 Aug 23;16(1):105. doi: 10.1186/s13073-024-01374-9.
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Gut microbiome composition and metabolic activity in women with diverticulitis.
女性憩室炎患者的肠道微生物组组成和代谢活性。
Nat Commun. 2024 Apr 29;15(1):3612. doi: 10.1038/s41467-024-47859-4.
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Scand J Gastroenterol. 2023 Jul-Dec;58(10):1131-1138. doi: 10.1080/00365521.2023.2194010. Epub 2023 Mar 29.
5
The Microbiome of Complicated Diverticulitis: An Imbalance of Sulfur-Metabolizing Bacteria.复杂性憩室炎的微生物组:硫代谢细菌失衡。
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