Li Tanjian, Jiang Na, Liang Xin, Li Xinya, Li Yaqin, Huang Yuting, Wang Yu
School of Nursing, Jinan University, Guangzhou, Guangdong, China.
School of Health, Binzhou Polytechnic, Binzhou, Shandong, China.
Front Endocrinol (Lausanne). 2024 Dec 16;15:1457956. doi: 10.3389/fendo.2024.1457956. eCollection 2024.
There is growing evidence that deficiencies in specific nutrients can impact testosterone levels in older men. However, research examining the predictive value of overall nutritional status on testosterone levels remains limited. The Geriatric Nutritional Risk Index (GNRI) is an effective tool for assessing the nutritional status of the elderly. Therefore, this study aimed to investigate the potential correlation between the GNRI and serum total testosterone (TT).
A representative sample of U.S. males aged 60 years and older who participated in the National Health and Nutrition Examination Survey (NHANES) cycles from 2011 to 2016 was utilized for this cross-sectional study. The research included a total of 829 older adults. Tandem mass spectrometry and liquid chromatography were employed to quantify TT. To examine the association between GNRI and TT, restricted cubic splines (RCS) and weighted multivariate regression analyses were conducted. Subgroup analysis was performed to identify the variables influencing the positive association between GNRI and TT. Additionally, a sensitivity analysis was carried out to compare the weighted and unweighted data.
After adjusting for all other factors, a positive association was found between GNRI and TT. The beta coefficient was 5.59, with a 95% confidence interval of 2.16 to 9.01, and a p-value of 0.003. Compared to the lowest quartile of GNRI (Q1), the second quartile (Q2), third quartile (Q3), and fourth quartile (Q4) significantly increased the level of TT. The beta coefficients for Q2, Q3, and Q4 were 70.15 (p = 0.022), 104.40 (p < 0.001), and 84.83 (p < 0.001), respectively. In subgroup analyses, statistically significant associations were observed among participants who did not have diabetes, had hypertension, and had a BMI of 24.9 or less. According to the sensitivity analysis, unweighted data also found GNRI to be associated with TT (beta = 3.09, P = 0.031).
A positive correlation was identified between the GNRI and TT in the elderly male population of the United States. Further prospective studies with larger sample sizes are needed to confirm the causal relationship between GNRI and TT.
越来越多的证据表明，特定营养素缺乏会影响老年男性的睾酮水平。然而，关于整体营养状况对睾酮水平预测价值的研究仍然有限。老年营养风险指数（GNRI）是评估老年人营养状况的有效工具。因此，本研究旨在探讨GNRI与血清总睾酮（TT）之间的潜在相关性。
本横断面研究使用了2011年至2016年参加美国国家健康与营养检查调查（NHANES）的60岁及以上美国男性的代表性样本。该研究共纳入829名老年人。采用串联质谱法和液相色谱法对TT进行定量。为了检验GNRI与TT之间的关联，进行了受限立方样条（RCS）和加权多元回归分析。进行亚组分析以确定影响GNRI与TT之间正相关的变量。此外，进行了敏感性分析以比较加权和未加权数据。
在调整所有其他因素后，发现GNRI与TT之间存在正相关。β系数为5.59，95%置信区间为2.16至9.01，p值为0.003。与GNRI的最低四分位数（Q1）相比，第二四分位数（Q2）、第三四分位数（Q3）和第四四分位数（Q4）显著提高了TT水平。Q2、Q3和Q4的β系数分别为70.15（p = 0.022）、104.40（p < 0.001）和84.83（p < 0.001）。在亚组分析中，在没有糖尿病、患有高血压且BMI为24.9或更低的参与者中观察到具有统计学意义的关联。根据敏感性分析，未加权数据也发现GNRI与TT相关（β = 3.09，P = 0.031）。
在美国老年男性人群中，GNRI与TT之间存在正相关。需要进一步进行更大样本量的前瞻性研究来证实GNRI与TT之间的因果关系。
