Li Chengjun, Sun Yiyan, Wu Hongyun, Li Xiaotong, Peng Wei
Department of Neurology, Huangdao District Hospital of Traditional Chinese Medicine.
Rehabilitation Medicine School of Shanghai University of Traditional Chinese Medicine.
Int Heart J. 2025 Jan 31;66(1):13-20. doi: 10.1536/ihj.24-232. Epub 2025 Jan 17.
There is growing evidence that body nutritional status influences the development of cardiovascular disease, particularly in the elderly population. The Geriatric Nutritional Risk Index (GNRI), as a tool for assessing the nutritional status and nutritional risk of elderly individuals, is applied in clinical practice. This study aimed to elucidate the relationship between GNRI and cardiovascular disease in the elderly and to assess the impact of nutritional status on cardiovascular disease.This study is a cross-sectional study based on the National Health and Nutrition Examination Survey (NHANES) database. The data for this investigation were obtained from the NHANES database from 2007 to 2018, which included 10,277 individuals aged 60 years and older. The relationship between GNRI and cardiovascular disease in the elderly was investigated using weighted multivariable logistic regression models, and smooth fitting curves were drawn to explore their association. In addition, subgroup analyses were used to explore population differences.In this study, after adjusting for all confounding variables, the odds ratio and 95% confidence intervals (CI) of the model were 0.98 (0.96, 1.00), with no statistically significant association. Smooth fitting curves showed a nonlinear correlation between GNRI and cardiovascular disease. We found an inflection point (GNRI = 139.55). Moreover, GNRI was negatively associated with cardiovascular disease in the elderly before the inflection point and not statistically significant after the inflection point.In this large cross-sectional study, we found a nonlinear correlation between GNRI and cardiovascular disease in the general elderly population in the United States.
越来越多的证据表明，身体营养状况会影响心血管疾病的发展，尤其是在老年人群中。老年营养风险指数（GNRI）作为评估老年人营养状况和营养风险的工具，已应用于临床实践。本研究旨在阐明老年人中GNRI与心血管疾病之间的关系，并评估营养状况对心血管疾病的影响。
本研究是一项基于美国国家健康与营养检查调查（NHANES）数据库的横断面研究。本调查的数据来自2007年至2018年的NHANES数据库，其中包括10277名60岁及以上的个体。使用加权多变量逻辑回归模型研究老年人中GNRI与心血管疾病之间的关系，并绘制平滑拟合曲线以探索它们之间的关联。此外，采用亚组分析来探索人群差异。
在本研究中，在调整所有混杂变量后，模型的优势比和95%置信区间（CI）为0.98（0.96，1.00），无统计学显著关联。平滑拟合曲线显示GNRI与心血管疾病之间存在非线性相关性。我们发现了一个拐点（GNRI = 139.55）。此外，在拐点之前，GNRI与老年人的心血管疾病呈负相关，在拐点之后无统计学显著性。
在这项大型横断面研究中，我们发现美国一般老年人群中GNRI与心血管疾病之间存在非线性相关性。
