Walsh C, Polley E H
J Neurosci. 1985 Mar;5(3):741-50. doi: 10.1523/JNEUROSCI.05-03-00741.1985.
The ganglion cells of the cat's retina form several classes distinguishable in terms of soma size, axon diameter, dendritic morphology, physiological properties, and central connections. Labeling with [3H]thymidine shows that the ganglion cells which survive in the adult are produced as several temporally shifted, overlapping waves: medium-sized cells are produced before large cells, whereas the smallest ganglion cells are produced throughout the period of ganglion cell generation (Walsh, C., E. H. Polley, T. L. Hickey, and R. W. Guillery (1983) Nature 302: 611-614). Large cells and medium-sized cells show the same distinctive pattern of production, forming rough spirals around the area centralis. The oldest cells tend to lie superior and nasal to the area centralis, whereas cells in the inferior nasal retina and inferior temporal retina are, in general, progressively younger. Within each retinal quadrant, cells nearer the area centralis tend to be older than cells in the periphery, but there is substantial overlap. The retinal raphe divides the superior temporal quadrant into two zones with different patterns of cell addition. Superior temporal retina near the vertical meridian adds cells only slightly later than superior nasal retina, whereas superior temporal retina near the horizontal meridian adds cells very late, contemporaneously with inferior temporal retina. The broader wave of production of smaller ganglion cells seems to follow this same spiral pattern at its beginning and end. The presence of the area centralis as a nodal point about which ganglion cell production in the retinal quadrants pivots suggests that the area centralis is already an important retinal landmark even at the earliest stages of retinal development. This sequence of ganglion cell production differs markedly from that seen in the retinae of nonmammalian vertebrates, where new ganglion cells are added as concentric rings to the retinal periphery, and also bears no simple relationship to the cat's retinal decussation line. However, it can be related in a straightforward manner to the organization of axons in the cat's optic tract, suggesting that the fiber order in the tract represents a grouping of fibers by age.
猫视网膜的神经节细胞可分为几类，可根据细胞体大小、轴突直径、树突形态、生理特性和中枢连接来区分。用[3H]胸腺嘧啶核苷标记显示，成年后存活的神经节细胞是分几个时间上有偏移且相互重叠的波产生的：中等大小的细胞比大细胞产生得早，而最小的神经节细胞在神经节细胞产生的整个时期都有产生（沃尔什，C.，E.H.波利，T.L.希基，和R.W.吉列里（1983年）《自然》302：611 - 614）。大细胞和中等大小的细胞表现出相同的独特产生模式，围绕中央区形成大致的螺旋。最老的细胞往往位于中央区的上方和鼻侧，而鼻下视网膜和颞下视网膜中的细胞通常逐渐年轻。在每个视网膜象限内，靠近中央区的细胞往往比周边的细胞老，但有大量重叠。视网膜中缝将颞上象限分为两个细胞添加模式不同的区域。靠近垂直子午线的颞上视网膜添加细胞的时间仅比鼻上视网膜稍晚，而靠近水平子午线的颞上视网膜添加细胞非常晚，与颞下视网膜同时。较小神经节细胞产生的更广泛波在开始和结束时似乎遵循相同的螺旋模式。中央区作为视网膜象限中神经节细胞产生围绕其旋转的节点的存在表明，即使在视网膜发育的最早阶段，中央区已经是一个重要的视网膜标志。这种神经节细胞产生的顺序与非哺乳动物脊椎动物视网膜中所见的明显不同，在非哺乳动物脊椎动物视网膜中，新的神经节细胞以同心环的形式添加到视网膜周边，并且与猫的视网膜交叉线也没有简单的关系。然而，它可以直接与猫视束中轴突的组织相关，这表明视束中的纤维顺序代表了按年龄分组的纤维。
