Chen Xiuze, Kang Haixian, Xiao Yechen
Department of Biotechnology, Basic Medical School, Guangdong Medical University, Dongguan 523808, China.
Shunde Women and Children's Hospital of Guangdong Medical University, Foshan 528300, China.
IBRO Neurosci Rep. 2024 Dec 6;17:503-512. doi: 10.1016/j.ibneur.2024.12.003. eCollection 2024 Dec.
Serum and glucocorticoid-regulated kinase 1 (SGK1), a member of the AGC family of serine/threonine protein kinases, is one of the most conserved protein kinases in eukaryotic evolution. SGK1 is expressed to varying degrees in various types of cells throughout the body, and plays an important role in hypertension, ion channels, oxidative stress, neurological disorders, and cardiovascular regulation. In recent years, a number of scholars have devoted themselves to the study of the role and function of SGK1 in neurological diseases. Therefore, this article reviews the role of SGK1 in Alzheimer's disease, Parkinson's disease, epilepsy, stroke and other neurological diseases in recent years, and puts forward some insights on the role of SGK1 in neurological diseases and its relationship with disease activities.
血清和糖皮质激素调节激酶1（SGK1）是丝氨酸/苏氨酸蛋白激酶AGC家族的成员之一，是真核生物进化中最保守的蛋白激酶之一。SGK1在全身各种类型的细胞中均有不同程度的表达，在高血压、离子通道、氧化应激、神经疾病和心血管调节中发挥重要作用。近年来，许多学者致力于研究SGK1在神经疾病中的作用和功能。因此，本文综述了近年来SGK1在阿尔茨海默病、帕金森病、癫痫、中风等神经疾病中的作用，并对SGK1在神经疾病中的作用及其与疾病活动的关系提出了一些见解。
