Liu Zikang, Dai Binbin, Bao Jiwen, Pan Yangbin
Department of Nephrology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China.
Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China.
Front Immunol. 2024 Dec 16;15:1498808. doi: 10.3389/fimmu.2024.1498808. eCollection 2024.
Kidney immune homeostasis is intricately linked to T cells. Inappropriate differentiation, activation, and effector functions of T cells lead to a spectrum of kidney disease. While executing immune functions, T cells undergo a series of metabolic rewiring to meet the rapid energy demand. The key enzymes and metabolites involved in T cell metabolism metabolically and epigenetically modulate T cells' differentiation, activation, and effector functions, thereby being capable of modulating kidney immune homeostasis. In this review, we first summarize the latest advancements in T cell immunometabolism. Second, we outline the alterations in the renal microenvironment under certain kidney disease conditions. Ultimately, we highlight the metabolic modulation of T cells within kidney immune homeostasis, which may shed light on new strategies for treating kidney disease.
肾脏免疫稳态与T细胞有着复杂的联系。T细胞不适当的分化、激活和效应功能会导致一系列肾脏疾病。在执行免疫功能时，T细胞会经历一系列代谢重编程以满足快速的能量需求。参与T细胞代谢的关键酶和代谢产物在代谢和表观遗传水平上调节T细胞的分化、激活和效应功能，从而能够调节肾脏免疫稳态。在这篇综述中，我们首先总结T细胞免疫代谢的最新进展。其次，我们概述某些肾脏疾病条件下肾脏微环境的改变。最后，我们强调肾脏免疫稳态中T细胞的代谢调节，这可能为肾脏疾病的治疗提供新策略。
