Antiviral activity of on HSV-1, 2 .

BACKGROUND AND OBJECTIVES

Medicinal plants are the primary treatment for many infectious and non-infectious diseases. In this study, we evaluated the antiviral activity of against herpes simplex viruses 1 and 2, and compared it with the antiviral drug acyclovir.

MATERIALS AND METHODS

In our experimental study, was dissolved in DMSO, then diluted in DMEM medium. Acyclovir was used at a concentration of 100 μM in all procedures. The antiherpetic activity and Antiviral activity of were evaluated in Vero cells (African green monkey kidney cells) by using the plaque reduction assay.

RESULTS

Inhibitory concentrations of 50% (IC) of for HSV-1 and HSV-2 were determined at 0.00025% and 0.00015%, respectively. was introduced at various stages of viral infection and significantly inhibited HSV-1 and HSV-2 infectivity by > 95.5% and 89%, respectively, when virus was pre-treated before addition to the cells. No HSV-1 or HSV-2 activity was detected in cells treated prior to and following viral infection.

CONCLUSION

These results indicate that demonstrates antiherpetic activity in the early phase of viral infection and could be used as potential antiviral agent.