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阿魏中倍半萜香豆素对单纯疱疹病毒1型的抗病毒活性评估

Anti-Viral Evaluation of Sesquiterpene Coumarins from Ferula assa-foetida against HSV-1.

作者信息

Ghannadi Alireza, Fattahian Khadijeh, Shokoohinia Yalda, Behbahani Mandana, Shahnoush Alireza

机构信息

Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.

Novel Drug Delivery Research Center & Department of Pharmacognosy and Biotechnology, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.

出版信息

Iran J Pharm Res. 2014 Spring;13(2):523-30.

PMID:25237347
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4157027/
Abstract

Several complications attributed with Herpes virus related infections and the emergence of drug resistant viruses prompt scientists to search for new drugs. Several terpenoids and coumarins have shown anti HSV effects while no sesquiterpene coumarins have been previously tested for HSV treatment. Three sesquiterpene coumarins badrakemin acetate (1), kellerin (2) and samarcandin diastereomer (3) were isolated from the gum resin of Ferula assa-foetida, a herbal medicine with antimicrobial, antiprotozoal and antiviral effects. Compounds were identified by 1D and 2D- NMR spectroscopies and comparison with literature data. A comparative evaluation of cytotoxicity and antiviral activity showed that kellerin (2) could significantly inhibit the cytopathic effects and reduce the viral titre of the herpes virus type 1 (HSV-1) DNA viral strain KOS at concentrations of 10, 5 and 2.5 µg/mL.

摘要

几种与疱疹病毒相关感染以及耐药病毒出现有关的并发症促使科学家们寻找新药。几种萜类化合物和香豆素已显示出抗单纯疱疹病毒（HSV）的作用，而此前尚未对倍半萜香豆素进行过HSV治疗测试。从具有抗菌、抗原生动物和抗病毒作用的草药阿魏（Ferula assa-foetida）的树胶树脂中分离出了三种倍半萜香豆素——乙酸巴德雷明（1）、凯莱林（2）和萨马坎丁非对映体（3）。通过一维和二维核磁共振光谱并与文献数据比较对化合物进行了鉴定。细胞毒性和抗病毒活性的比较评估表明，凯莱林（2）在浓度为10、5和2.5μg/mL时可显著抑制细胞病变效应并降低1型疱疹病毒（HSV-1）DNA病毒株KOS的病毒滴度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f29f/4157027/039b0fc46a31/ijpr-13-523-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f29f/4157027/82b5b0b1c893/ijpr-13-523-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f29f/4157027/79a383d7e8b7/ijpr-13-523-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f29f/4157027/750a369a4660/ijpr-13-523-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f29f/4157027/039b0fc46a31/ijpr-13-523-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f29f/4157027/82b5b0b1c893/ijpr-13-523-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f29f/4157027/79a383d7e8b7/ijpr-13-523-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f29f/4157027/750a369a4660/ijpr-13-523-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f29f/4157027/039b0fc46a31/ijpr-13-523-g004.jpg

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