Du Juan, Luo Hui, Ye Shuang, Zhang Hui, Zheng Zhen, Liu Kaitai
The Affiliated Lihuili Hospital of Ningbo University, Ningbo, China.
Front Oncol. 2024 Dec 16;14:1436576. doi: 10.3389/fonc.2024.1436576. eCollection 2024.
Interferon-induced protein 44-like () is regarded as an immune-related gene and is a member of interferon-stimulated genes (ISGs). They participate in network transduction, and its own epigenetic modifications, apoptosis, cell-matrix formation, and many other pathways in tumors, autoimmune diseases, and viral infections. The current review provides a comprehensive overview of the onset and biological mechanisms of and its potential clinical applications in malignant tumors and non-neoplastic diseases.
干扰素诱导蛋白44样蛋白()被视为一种免疫相关基因,是干扰素刺激基因(ISGs)的成员。它们参与网络转导,以及其自身在肿瘤、自身免疫性疾病和病毒感染中的表观遗传修饰、细胞凋亡、细胞-基质形成等许多途径。本综述全面概述了该蛋白的发病机制和生物学机制及其在恶性肿瘤和非肿瘤性疾病中的潜在临床应用。