Bricault Sarah, Dawson Miranda, Lee Jiyoung, Desai Mitul, Schwalm Miriam, Chung Kevin Sunho, DeTienne Elizabeth, Fagan Erinn, Li Nan, Becker Andrew, Muthupalani Sureshkumar, Fränken Jan-Philipp, Pinotsis Dimitris A, Jasanoff Alan
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, US.
Department of Biology, Massachusetts Institute of Technology, Cambridge, US.
Nat Commun. 2024 Dec 30;15(1):10820. doi: 10.1038/s41467-024-55064-6.
The correlational structure of brain activity dynamics in the absence of stimuli or behavior is often taken to reveal intrinsic properties of neural function. To test the limits of this assumption, we analyzed peripheral contributions to resting state activity measured by fMRI in unanesthetized, chemically immobilized male rats that emulate human neuroimaging conditions. We find that perturbation of somatosensory input channels modifies correlation strengths that relate somatosensory areas both to one another and to higher-order brain regions, despite the absence of ostensible stimuli or movements. Resting state effects are mediated by the same peripheral and thalamic structures that relay responses to overt sensory stimuli. The impact of basal peripheral input is reduced in a rat model of autism, which displays both lower somatosensory functional connectivity and insensitivity to vibrissa inactivation. These results demonstrate the influence of extrinsic influences on resting state brain phenotypes in health and disease.
在没有刺激或行为的情况下，大脑活动动力学的相关结构通常被认为揭示了神经功能的内在特性。为了测试这一假设的局限性，我们分析了在模仿人类神经成像条件的未麻醉、化学固定的雄性大鼠中，通过功能磁共振成像（fMRI）测量的外周对静息状态活动的贡献。我们发现，体感输入通道的扰动会改变相关强度，这种相关强度将体感区域相互之间以及与高阶脑区联系起来，尽管没有明显的刺激或运动。静息状态效应是由与传递对明显感觉刺激的反应相同的外周和丘脑结构介导的。在自闭症大鼠模型中，基础外周输入的影响有所降低，该模型表现出较低的体感功能连接性以及对触须失活不敏感。这些结果证明了外在影响在健康和疾病状态下对静息状态脑表型的作用。
