Swartz Johnna R, Carranza Angelica F, Tully Laura M, Knodt Annchen R, Jiang Janina, Irwin Michael R, Hostinar Camelia E
Department of Human Ecology, University of California, Davis, CA, United States.
Department of Human Ecology, University of California, Davis, CA, United States.
Brain Behav Immun. 2021 Jul;95:96-105. doi: 10.1016/j.bbi.2021.02.018. Epub 2021 Feb 23.
Relatively little is known about associations between peripheral inflammation and neural function in humans. Neuroimaging studies in adults have suggested that elevated peripheral inflammatory markers are associated with altered resting state functional connectivity (rsFC) in several brain networks associated with mood and cognition. Few studies have examined these associations in adolescents, yet scarce data from adolescents point to different networks than adult studies. The current study examined the associations between peripheral inflammation and rsFC in a community sample of adolescents (n = 70; age, 12-15 years; 32 female, 36 male, 2 nonbinary). After blood sampling, an fMRI scan was performed to assess rsFC. Assay for serum inflammatory markers, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP), was performed. Results indicated that higher TNF-α was associated with altered rsFC between the right amygdala and left striatum and between the right inferior frontal gyrus and left parietal cortex (p < 0.05 whole-brain corrected). Associations with IL-6 and CRP were not significant. In contrast with findings in adults, inflammation may have unique links with the connectivity of the developing adolescent brain. Results have implications for understanding how peripheral inflammation may influence connectivity during adolescence, when neural networks are undergoing major developmental changes.
关于人类外周炎症与神经功能之间的关联，人们了解相对较少。针对成年人的神经影像学研究表明，外周炎症标志物升高与几个与情绪和认知相关的脑网络静息态功能连接（rsFC）改变有关。很少有研究在青少年中检验这些关联，然而来自青少年的稀缺数据指向的网络与成人研究不同。本研究在一个青少年社区样本（n = 70；年龄12 - 15岁；32名女性，36名男性，2名非二元性别）中检验了外周炎症与rsFC之间的关联。采血后，进行功能磁共振成像扫描以评估rsFC。检测了血清炎症标志物，包括白细胞介素-6（IL - 6）、肿瘤坏死因子-α（TNF -α）和C反应蛋白（CRP）。结果表明，较高的TNF -α与右侧杏仁核和左侧纹状体之间以及右侧额下回和左侧顶叶皮质之间的rsFC改变有关（全脑校正p < 0.05）。与IL - 6和CRP的关联不显著。与成年人的研究结果相反，炎症可能与发育中的青少年大脑的连接性有独特的联系。这些结果对于理解外周炎症在神经网络正在经历重大发育变化的青春期如何影响连接性具有启示意义。
