Zou Mi, Feng Zuxi, Hu Kaibo, Shu Yuan, Li Ting, Peng Xiaogang, Chen Leifeng, Xiao Leyang, Zhang Shouhua, Xiong Ting, Deng Xueqiang, Peng Jie, Hao Liang
Department of Orthopedics, The Second Affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi Province, China.
The Second Clinical Medical College, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi Province, China.
Sci Rep. 2024 Dec 30;14(1):31636. doi: 10.1038/s41598-024-80603-y.
The DNA cross-link repair 1B (DCLRE1B) gene is involved in repairing cross-links between DNA strands, including those associated with Hoyeraal-Hreidarsson syndrome and congenital dyskeratosis. However, its role in tumours is not well understood. DCLRE1B expression profiles were examined in tumour tissues and normal tissues using TCGA, GTEx, and TARGET datasets. Additionally, we performed experiments with clinical melanoma samples to verify DCLRE1B expression patterns. We also performed pancancer analyses to investigate the diverse roles of DCLRE1B in the biological functions of various cancers. DCLRE1B exhibited distinct expression patterns and played crucial prognostic roles in most tumours. In particular, high expression of DCLRE1B in melanoma was significantly correlated with a poor prognosis and increased malignancy. DCLRE1B was also found to be associated with the immune landscape and various immune biomarkers and regulators. Furthermore, our analysis identified potential small molecules that could target DCLRE1B in different cancer types. The DCLRE1B gene may be involved in the development and occurrence of a variety of cancers. Additionally, DCLRE1B affects various tumour types not only by mediating DNA repair but also by shaping the differential immune microenvironment. In conclusion, our research offers fresh perspectives on the diagnosis and treatment of different types of cancers.
DNA交联修复1B（DCLRE1B）基因参与修复DNA链之间的交联，包括与霍耶拉尔 - 赫雷达尔松综合征和先天性角化不良相关的交联。然而，其在肿瘤中的作用尚不清楚。使用TCGA、GTEx和TARGET数据集检测肿瘤组织和正常组织中的DCLRE1B表达谱。此外，我们对临床黑色素瘤样本进行实验以验证DCLRE1B表达模式。我们还进行了泛癌分析，以研究DCLRE1B在各种癌症生物学功能中的不同作用。DCLRE1B在大多数肿瘤中表现出不同的表达模式并发挥关键的预后作用。特别是，DCLRE1B在黑色素瘤中的高表达与预后不良和恶性程度增加显著相关。还发现DCLRE1B与免疫格局以及各种免疫生物标志物和调节因子有关。此外，我们的分析确定了可在不同癌症类型中靶向DCLRE1B的潜在小分子。DCLRE1B基因可能参与多种癌症的发生发展。此外，DCLRE1B不仅通过介导DNA修复，还通过塑造不同的免疫微环境来影响各种肿瘤类型。总之，我们的研究为不同类型癌症的诊断和治疗提供了新的视角。
