Ling He, Deng Gaoyong, Xia Shaohuai, Li Wencai, Lu Rongbin, Lin Mingjian, Huang Zhao
Department of Orthopedics Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, No. 6 ShuangYong Road, Nanning, 530022, Guangxi, China.
Department of Spine Surgery, The Affiliated Hospital of Guilin Medical University, Guilin, 541001, Guangxi, China.
Sci Rep. 2024 Dec 30;14(1):31919. doi: 10.1038/s41598-024-83429-w.
Cervical spondylotic myelopathy (CSM) is a neurological disorder characterized by degenerative changes in the spinal cord and compression of the spinal cord and its adjacent structures due to various reasons, such as intervertebral disc herniation. The Japan Orthopaedic Association score is a disease-specific outcome tool that provides quantitative measurements for CSM patients. At present, no scholars have developed a model that can directly predict the prognosis of CSM patients. This study used binary logistic regression analysis to identify clinical independent predictive factors, and then used R language to construct a nomogram. The results showed that Hb (0.71 [0.51, 0.99]), LYM (0.32 [0.22, 0.46]), and ALB (0.32 [0.23, 0.45]) were independent predictive factors. Good prediction performance with modest errors was shown by the nomogram in both the training and validation groups. Hb, LYM, ALB are independent predictors of the prognosis of ACDF in CSM patients. The constructed nomogram can help clinicians assess and treat patients early, benefiting more patients.
脊髓型颈椎病（CSM）是一种神经疾病，其特征是脊髓发生退行性改变，并由于各种原因（如椎间盘突出）导致脊髓及其相邻结构受到压迫。日本骨科协会评分是一种针对特定疾病的结局工具，可为CSM患者提供定量测量。目前，尚无学者开发出能够直接预测CSM患者预后的模型。本研究采用二元逻辑回归分析来确定临床独立预测因素，然后使用R语言构建列线图。结果显示，血红蛋白（Hb，0.71 [0.51, 0.99]）、淋巴细胞（LYM，0.32 [0.22, 0.46]）和白蛋白（ALB，0.32 [0.23, 0.45]）是独立预测因素。列线图在训练组和验证组中均显示出良好的预测性能且误差适中。Hb、LYM、ALB是CSM患者前路颈椎间盘切除融合术（ACDF）预后的独立预测指标。构建的列线图可帮助临床医生早期评估和治疗患者，使更多患者受益。
