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[环境应激源对心血管健康的影响]

[The effects of environmental stressors on cardiovascular health].

作者信息

Münzel Thomas, Kuntic Marin, Stamm Paul, Lelieveld Jos, Daiber Andreas

机构信息

Zentrum für Kardiologie, Universitätsmedizin Mainz, Johannes Gutenberg-Universität, Langenbeckstraße 1, 55131, Mainz, Deutschland.

Abteilung für Atmosphärenchemie, Max-Planck-Institut für Chemie, Mainz, Deutschland.

出版信息

Inn Med (Heidelb). 2025 Apr;66(4):373-384. doi: 10.1007/s00108-024-01823-y. Epub 2024 Dec 30.

Abstract

Noncommunicable diseases (NCDs) are responsible for the premature deaths of more than 38 million people each year, making them the leading cause of the global burden of disease, accounting for 70% of global mortality. The majority of these deaths are caused by cardiovascular diseases. The risk of NCDs is closely related to exposure to environmental stressors such as air pollution, noise pollution, artificial light at night, and climate change, including extreme heat, sandstorms, and wildfires. In addition to the traditional risk factors for cardiovascular diseases such as diabetes, high blood pressure, smoking, hypercholesterolemia and genetic predisposition, there is increasing evidence that physicochemical factors in the environment significantly contribute to the high NCD numbers. In addition, urbanization is related to the accumulation and intensification of these stressors. This expert review will summarize the epidemiology and pathophysiology of environmental stressors with a focus on cardiovascular NCDs. In addition, solutions and measures to mitigate the effects of environmental risks, especially concerning cardiovascular diseases, will be discussed.

摘要

非传染性疾病(NCDs)每年导致超过3800万人过早死亡,使其成为全球疾病负担的主要原因,占全球死亡率的70%。这些死亡大多数由心血管疾病引起。非传染性疾病的风险与接触环境应激源密切相关,如空气污染、噪音污染、夜间人造光以及气候变化,包括极端高温、沙尘暴和野火。除了心血管疾病的传统风险因素,如糖尿病、高血压、吸烟、高胆固醇血症和遗传易感性外,越来越多的证据表明环境中的物理化学因素对非传染性疾病的高发病率有显著影响。此外,城市化与这些应激源的积累和强化有关。本专家综述将总结环境应激源的流行病学和病理生理学,重点关注心血管非传染性疾病。此外,还将讨论减轻环境风险影响的解决方案和措施,特别是与心血管疾病相关的措施。

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