• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

癌相关成纤维细胞衍生的细胞外囊泡将长链非编码RNA MAPKAPK5-AS1转运至肝癌细胞中并促进恶性细胞增殖。

CAF-EVs carry lncRNA MAPKAPK5-AS1 into hepatocellular carcinoma cells and promote malignant cell proliferation.

作者信息

Sheng Lin, Lin Junmei, Zhang Yili, Chen Yanping, Ye Xuxing, Wang Xiaobo

机构信息

The department of internal medicine, Jinhua Municipal Central Hospital, Jinhua, China.

Department of Traditional Chinese Medicine, Jinhua Municipal Central Hospital, Jinhua, China.

出版信息

Commun Biol. 2024 Dec 30;7(1):1711. doi: 10.1038/s42003-024-07428-3.

DOI:10.1038/s42003-024-07428-3
PMID:39739005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11685398/
Abstract

Hepatocellular carcinoma (HCC) is an aggressive malignancy with poor prognosis. LncRNA MAPKAPK5-AS1 is a potential oncogene and contributes to HCC cell malignant proliferation. This study explores the role of MAPKAPK5-AS1 carried by carcinoma-associated fibroblasts-derived extracellular vesicles (CAF-EVs) in HCC cell proliferation. Our findings reveal that CAF-EVs promotes HCC cell proliferation by delivering MAPKAPK5-AS1, which binds to and inhibits SMURF2 and stabilizes TCF12. SMURF2 leads to TCF12 ubiquitination and degradation. TCF12 upregulates FOXH1 expression. In animal model, CAF-EVs enhances tumor growth by stabilizing TCF12 via MAPKAPK5-AS1 and activating FOXH1 transcription. In conclusion, CAF-EVs carrying MAPKAPK5-AS1 stabilizes TCF12 expression by competitively inhibiting SMURF2, thus promoting TCF12-mediated FOXH1 transcription and driving HCC cell proliferation. Our findings may offer insights for HCC treatment and suggest potential targets for future treatments, opening avenues for HCC therapies.

摘要

肝细胞癌（HCC）是一种侵袭性恶性肿瘤，预后较差。长链非编码RNA MAPKAPK5-AS1是一种潜在的癌基因，促进肝癌细胞的恶性增殖。本研究探讨了癌相关成纤维细胞衍生的细胞外囊泡（CAF-EVs）携带的MAPKAPK5-AS1在肝癌细胞增殖中的作用。我们的研究结果表明，CAF-EVs通过传递MAPKAPK5-AS1促进肝癌细胞增殖，MAPKAPK5-AS1与SMURF2结合并抑制其活性，从而稳定TCF12。SMURF2导致TCF12泛素化和降解。TCF12上调FOXH1表达。在动物模型中，CAF-EVs通过MAPKAPK5-AS1稳定TCF12并激活FOXH1转录来促进肿瘤生长。总之，携带MAPKAPK5-AS1的CAF-EVs通过竞争性抑制SMURF2来稳定TCF12表达，从而促进TCF12介导的FOXH1转录并驱动肝癌细胞增殖。我们的研究结果可能为肝癌治疗提供见解，并为未来治疗提出潜在靶点，为肝癌治疗开辟新途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e5/11685398/0012f4b4dfdc/42003_2024_7428_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e5/11685398/2144e63911f4/42003_2024_7428_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e5/11685398/bf4bc054a11b/42003_2024_7428_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e5/11685398/3ba848fa8555/42003_2024_7428_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e5/11685398/acc3c02eac6c/42003_2024_7428_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e5/11685398/c1f7ef5e71fa/42003_2024_7428_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e5/11685398/a7d0a76c55aa/42003_2024_7428_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e5/11685398/614511d8a3c1/42003_2024_7428_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e5/11685398/3bdb36d7bce2/42003_2024_7428_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e5/11685398/52429d6e1da1/42003_2024_7428_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e5/11685398/0012f4b4dfdc/42003_2024_7428_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e5/11685398/2144e63911f4/42003_2024_7428_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e5/11685398/bf4bc054a11b/42003_2024_7428_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e5/11685398/3ba848fa8555/42003_2024_7428_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e5/11685398/acc3c02eac6c/42003_2024_7428_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e5/11685398/c1f7ef5e71fa/42003_2024_7428_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e5/11685398/a7d0a76c55aa/42003_2024_7428_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e5/11685398/614511d8a3c1/42003_2024_7428_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e5/11685398/3bdb36d7bce2/42003_2024_7428_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e5/11685398/52429d6e1da1/42003_2024_7428_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e5/11685398/0012f4b4dfdc/42003_2024_7428_Fig10_HTML.jpg

相似文献

1
CAF-EVs carry lncRNA MAPKAPK5-AS1 into hepatocellular carcinoma cells and promote malignant cell proliferation.癌相关成纤维细胞衍生的细胞外囊泡将长链非编码RNA MAPKAPK5-AS1转运至肝癌细胞中并促进恶性细胞增殖。
Commun Biol. 2024 Dec 30;7(1):1711. doi: 10.1038/s42003-024-07428-3.
2
Long non-coding RNA MAPKAPK5-AS1/PLAGL2/HIF-1α signaling loop promotes hepatocellular carcinoma progression.长非编码 RNA MAPKAPK5-AS1/PLAGL2/HIF-1α 信号通路促进肝细胞癌进展。
J Exp Clin Cancer Res. 2021 Feb 17;40(1):72. doi: 10.1186/s13046-021-01868-z.
3
MAPKAPK5-AS1 drives the progression of hepatocellular carcinoma via regulating miR-429/ZEB1 axis.MAPKAPK5-AS1 通过调控 miR-429/ZEB1 轴促进肝细胞癌的进展。
BMC Mol Cell Biol. 2022 Apr 25;23(1):21. doi: 10.1186/s12860-022-00420-x.
4
Down-regulated lncRNA TP73-AS1 reduces radioresistance in hepatocellular carcinoma via the PTEN/Akt signaling pathway.下调的长链非编码 RNA TP73-AS1 通过 PTEN/Akt 信号通路降低肝癌的放射抵抗性。
Cell Cycle. 2019 Nov;18(22):3177-3188. doi: 10.1080/15384101.2019.1671089. Epub 2019 Sep 29.
5
Long noncoding RNA ZFPM2-AS1 acts as a miRNA sponge and promotes cell invasion through regulation of miR-139/GDF10 in hepatocellular carcinoma.长链非编码 RNA ZFPM2-AS1 通过调控 miR-139/GDF10 促进肝癌细胞侵袭。
J Exp Clin Cancer Res. 2020 Aug 14;39(1):159. doi: 10.1186/s13046-020-01664-1.
6
Long noncoding RNA MAPKAPK5-AS1 promotes metastasis through regulation miR-376b-5p/ECT2 axis in hepatocellular carcinoma.长链非编码 RNA MAPKAPK5-AS1 通过调节 miR-376b-5p/ECT2 轴促进肝癌转移。
Dig Liver Dis. 2023 Jul;55(7):945-954. doi: 10.1016/j.dld.2022.11.024. Epub 2022 Dec 23.
7
N6-methyladenosine-modified long non-coding RNA promotes stemness and sorafenib resistance in hepatocellular carcinoma by upregulating SHOX2 expression.N6-甲基腺苷修饰的长链非编码RNA通过上调SHOX2表达促进肝细胞癌的干性和索拉非尼耐药性。
World J Gastroenterol. 2024 Dec 28;30(48):5174-5190. doi: 10.3748/wjg.v30.i48.5174.
8
Downregulation of lncRNA SBF2-AS1 inhibits hepatocellular carcinoma proliferation and migration by regulating the miR-361-5p/TGF-β1 signaling pathway.lncRNA SBF2-AS1 的下调通过调节 miR-361-5p/TGF-β1 信号通路抑制肝癌细胞的增殖和迁移。
Aging (Albany NY). 2021 Aug 2;13(15):19260-19271. doi: 10.18632/aging.203248.
9
HNF4A-AS1 inhibits the progression of hepatocellular carcinoma by promoting the ubiquitin-modulated degradation of PCBP2 and suppressing the stability of ARG2 mRNA.HNF4A-AS1 通过促进 PCBP2 的泛素修饰降解和抑制 ARG2 mRNA 的稳定性来抑制肝细胞癌的进展。
Int J Biol Sci. 2024 Sep 23;20(13):5087-5108. doi: 10.7150/ijbs.95276. eCollection 2024.
10
Extracellular vesicles derived from cancer-associated fibroblasts carry tumor-promotive microRNA-1228-3p to enhance the resistance of hepatocellular carcinoma cells to sorafenib.源自癌症相关成纤维细胞的细胞外囊泡携带促肿瘤的微小RNA-1228-3p，以增强肝癌细胞对索拉非尼的抗性。
Hum Cell. 2023 Jan;36(1):296-311. doi: 10.1007/s13577-022-00800-7. Epub 2022 Nov 23.

本文引用的文献

1
A positive feedback between PDIA3P1 and OCT4 promotes the cancer stem cell properties of esophageal squamous cell carcinoma.PDIA3P1 与 OCT4 之间的正反馈促进食管鳞癌细胞的癌症干细胞特性。
Cell Commun Signal. 2024 Jan 22;22(1):60. doi: 10.1186/s12964-024-01475-3.
2
JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles.JASPAR 2024：转录因子结合谱开放获取数据库的 20 周年纪念
Nucleic Acids Res. 2024 Jan 5;52(D1):D174-D182. doi: 10.1093/nar/gkad1059.
3
CircUSP10 promotes liver cancer progression by regulating miR-211-5p/TCF12/EMT signaling pathway.
环状USP10通过调控miR-211-5p/TCF12/EMT信号通路促进肝癌进展。
Heliyon. 2023 Oct 4;9(10):e20649. doi: 10.1016/j.heliyon.2023.e20649. eCollection 2023 Oct.
4
Loss of SMURF2 expression enhances RACK1 stability and promotes ovarian cancer progression.SMURF2 表达缺失增强 RACK1 的稳定性并促进卵巢癌进展。
Cell Death Differ. 2023 Nov;30(11):2382-2392. doi: 10.1038/s41418-023-01226-w. Epub 2023 Oct 12.
5
TCF12 Activates TGFB2 Expression to Promote the Malignant Progression of Melanoma.TCF12激活TGFB2表达以促进黑色素瘤的恶性进展。
Cancers (Basel). 2023 Sep 11;15(18):4505. doi: 10.3390/cancers15184505.
6
SMURF2 facilitates ubiquitin-mediated degradation of ID2 to attenuate lung cancer cell proliferation.SMURF2 促进 ID2 的泛素化介导降解，从而抑制肺癌细胞增殖。
Int J Biol Sci. 2023 Jun 26;19(11):3324-3340. doi: 10.7150/ijbs.80979. eCollection 2023.
7
Comprehensive analysis of FOXM1 immune infiltrates, m6a, glycolysis and ceRNA network in human hepatocellular carcinoma.全面分析人肝癌中 FOXM1 免疫浸润、m6A、糖酵解和 ceRNA 网络。
Front Immunol. 2023 May 10;14:1138524. doi: 10.3389/fimmu.2023.1138524. eCollection 2023.
8
The origins, roles and therapies of cancer associated fibroblast in liver cancer.肝癌中癌症相关成纤维细胞的起源、作用及治疗
Front Oncol. 2023 Mar 23;13:1151373. doi: 10.3389/fonc.2023.1151373. eCollection 2023.
9
Tumor microenvironment-mediated immune evasion in hepatocellular carcinoma.肿瘤微环境介导的肝细胞癌免疫逃逸。
Front Immunol. 2023 Feb 10;14:1133308. doi: 10.3389/fimmu.2023.1133308. eCollection 2023.
10
Long noncoding RNA MyD88 functions as a promising diagnostic biomarker in hepatocellular carcinoma.长链非编码 RNA MyD88 作为一种有前途的肝癌诊断生物标志物。
Front Endocrinol (Lausanne). 2023 Jan 30;14:938102. doi: 10.3389/fendo.2023.938102. eCollection 2023.