Jeong Eun-Jeong, Kim Eunjeong, Kim Yeon Soo
Department of Otorhinolaryngology-Head and Neck Surgery, Konyang University College of Medicine, Daejeon, Korea.
Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, 35365, Seoul, Korea.
Sci Rep. 2024 Dec 30;14(1):32102. doi: 10.1038/s41598-024-83680-1.
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous cancer with limited therapeutic options. Using publicly available datasets, we identified the WD repeat domain 54 (WDR54) gene as a potential therapeutic target in HNSCC. Gene expression profiling interactive analysis version 2 (GEPIA2) was used to identify genes differentially overexpressed in HNSCC. Our results showed that WDR54, a member of the WD40 repeat domain family, was overexpressed in HNSCC tumor samples. Analysis of three gene expression omnibus datasets showed that WDR54 was overexpressed in tumor samples. Using the UALCAN database, we showed that WDR54 expression in patients with HNSCC at different tumor stages gradually increased with disease progression. We confirmed the association between WDR54 and metastasis using TNMplot.com. WDR54 was overexpressed in metastatic samples compared to that in normal and tumor samples. Kaplan-Meier analysis showed that patients with high WDR54 levels had a poorer prognosis. Additionally, WDR54 expression was correlated with the epidermal growth factor receptor, which is frequently overexpressed in HNSCC. Our findings suggest that WDR54 is a promising biomarker and therapeutic target in HNSCC.
头颈部鳞状细胞癌（HNSCC）是一种异质性癌症，治疗选择有限。利用公开可用的数据集，我们确定WD重复结构域54（WDR54）基因是HNSCC中的一个潜在治疗靶点。使用基因表达谱交互分析版本2（GEPIA2）来鉴定在HNSCC中差异过表达的基因。我们的结果表明，WD40重复结构域家族成员WDR54在HNSCC肿瘤样本中过表达。对三个基因表达综合数据库的分析表明，WDR54在肿瘤样本中过表达。使用UALCAN数据库，我们发现不同肿瘤分期的HNSCC患者中WDR54的表达随疾病进展逐渐增加。我们使用TNMplot.com证实了WDR54与转移之间的关联。与正常样本和肿瘤样本相比，WDR54在转移样本中过表达。Kaplan-Meier分析表明，WDR54水平高的患者预后较差。此外，WDR54的表达与表皮生长因子受体相关，表皮生长因子受体在HNSCC中经常过表达。我们的研究结果表明，WDR54是HNSCC中一个有前景的生物标志物和治疗靶点。
