Arkan Yousif Hawazin, Al-Ani Israa, Hajleh Maha N Abu, Matalqah Sina, Dayyih Wael Abu, Al-Dujaili Emad A
Department of Pharmaceutics and Pharmaceutical Technology, Pharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan.
Department of Cosmetic Science, Pharmacological and Diagnostic Research Centre, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman, Jordan.
J Cosmet Dermatol. 2025 Jan;24(1):e16706. doi: 10.1111/jocd.16706.
Coenzyme Q10 (CoQ10) is widely recognized for its powerful antioxidant properties, sparking considerable interest in its application within skincare treatments. However, its inherently poor water solubility has posed a major challenge in formulating effective skincare products.
This research aimed to develop and evaluate a water-soluble CoQ10 serum by forming a complex with hydroxypropyl β-cyclodextrin (HPβCD). The study focused on assessing its physicochemical properties, CoQ10 concentration, spread ability, viscosity, pH, physical stability, irritation potential, and diffusion performance. The complexation process was carried out using kneading and trituration techniques, with thorough characterization via validated analytical methods such as solubility tests, Fourier transform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC) analyses.
The CoQ10-HPβCD complex prepared using the trituration technique at a 2:1 ratio (CoQ10 to HPβCD) demonstrated superior water solubility, reaching 17.5 ± 1.8 mg mL, the highest among the tested formulations. Moreover, this formulation achieved the greatest encapsulation efficiency, retaining 71% ± 3.8% of CoQ10. FTIR and DSC analyses confirmed the successful formation of the complex. The formulated serum exhibited shear-thinning behavior, an optimal pH of 4.3 ± 0.2 closely aligning with the skin's natural acidity for enhanced compatibility-along with excellent spreadability and stability. Diffusion tests revealed a significant enhancement in solubility when CoQ10 was complexed, effectively overcoming its solubility barrier. Irritation tests validated the serum's safety for topical use.
This study successfully developed a CoQ10 serum that overcame its solubility limitation, demonstrating favorable properties for skincare application. With its strong physicochemical characteristics and biocompatibility, this formulation shows significant promise for broader incorporation into skincare products.
辅酶Q10（CoQ10）因其强大的抗氧化特性而广为人知，这引发了人们对其在护肤品中应用的浓厚兴趣。然而，其固有的低水溶性在配制有效的护肤产品方面构成了重大挑战。
本研究旨在通过与羟丙基-β-环糊精（HPβCD）形成复合物来开发和评估一种水溶性CoQ10精华液。该研究重点评估其理化性质、CoQ10浓度、铺展性、粘度、pH值、物理稳定性、刺激潜力和扩散性能。络合过程采用捏合和研磨技术进行，并通过溶解度测试、傅里叶变换红外光谱（FTIR）和差示扫描量热法（DSC）分析等经过验证的分析方法进行全面表征。
采用研磨技术以2:1的比例（CoQ10与HPβCD）制备的CoQ10-HPβCD复合物表现出卓越的水溶性，达到17.5±1.8mg/mL，是测试配方中最高的。此外，该配方实现了最大的包封效率，保留了71%±3.8%的CoQ10。FTIR和DSC分析证实了复合物的成功形成。配制的精华液表现出剪切变稀行为，最佳pH值为4.3±0.2，与皮肤的天然酸度密切匹配以增强相容性，同时具有出色的铺展性和稳定性。扩散测试表明，CoQ10络合后溶解度显著提高，有效克服了其溶解度障碍。刺激测试验证了该精华液局部使用的安全性。
本研究成功开发出一种克服了CoQ10溶解度限制的精华液，显示出在护肤品应用中的良好特性。凭借其强大的理化特性和生物相容性，该配方在更广泛地纳入护肤品方面具有显著前景。
