Hymes L C
J Urol. 1985 Mar;133(3):436-8. doi: 10.1016/s0022-5347(17)49010-0.
Fifteen children with episodes of painless hematuria without calculi and 8 others with calcareous urolithiasis were examined for hypercalciuria. All patients were normocalcemic and excreted excessive amounts of urinary calcium (greater than 4 mg. per kg. per day). A familial history for renal calculi was noted in 8 children with hematuria and in 5 with urolithiasis. Children with hematuria excreted greater amounts of calcium and presented at an earlier age compared to patients with renal calculi. After 7 days of a low calcium diet an oral calcium loading test was performed in children from both groups. Urinary calcium excretion and parathyroid activity were not different in the 2 clinical groups while fasting or after an oral calcium load. Absorptive and renal subtypes were found in patients with hematuria and urolithiasis. Treatment used to prevent the recurrence of calculi also was highly effective in resolving hematuria. Despite differences in age and clinical presentation, these children appeared metabolically similar and responded favorably to therapeutic regimens that reduce urinary calcium excretion.
对15例有无结石的无痛性血尿患儿及另外8例有含钙尿路结石的患儿进行了高钙尿症检查。所有患者血钙正常，但尿钙排泄量过多（大于4毫克/千克/天）。8例血尿患儿和5例尿路结石患儿有肾结石家族史。与肾结石患者相比，血尿患儿排出的钙量更多，发病年龄更早。两组患儿在低钙饮食7天后均进行了口服钙负荷试验。在空腹或口服钙负荷后，两个临床组的尿钙排泄和甲状旁腺活性并无差异。血尿和尿路结石患者中均发现了吸收型和肾型亚型。用于预防结石复发的治疗方法对解决血尿也非常有效。尽管年龄和临床表现存在差异，但这些患儿在代谢方面似乎相似，对减少尿钙排泄的治疗方案反应良好。
