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一种用于高危人群多癌早期检测的经济高效的两步法。

A Cost-Effective Two-Step Approach for Multi-Cancer Early Detection in High-Risk Populations.

作者信息

Geng Shuaipeng, Li Shiyong, Wu Wei, Chang Yinyin, Mao Mao

机构信息

Clinical Laboratories, Shenyou Bio, Zhengzhou, China.

Research & Development, SeekIn Inc, Shenzhen, China.

出版信息

Cancer Res Commun. 2025 Jan 1;5(1):150-156. doi: 10.1158/2767-9764.CRC-24-0508.

DOI:10.1158/2767-9764.CRC-24-0508
PMID:39740056
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11758400/
Abstract

Large-scale screening inevitably leads to significant financial burdens on the healthcare system, which is a key factor constraining nationwide screenings. The two-step MCED approach not only maintains comparable performance but also substantially alleviates financial strains compared with the direct use of next-generation sequencing-based MCED tests for massive screenings.

摘要

大规模筛查不可避免地给医疗系统带来巨大的经济负担，这是限制全国性筛查的一个关键因素。与直接使用基于下一代测序的多癌早筛检测进行大规模筛查相比，两步式多癌早筛方法不仅保持了相当的性能，还显著减轻了经济压力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc55/11758400/b3b3eebcd0f0/crc-24-0508_f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc55/11758400/ffc640c45d74/crc-24-0508_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc55/11758400/2905bf357ea0/crc-24-0508_f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc55/11758400/aee8266ff0a3/crc-24-0508_f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc55/11758400/b3b3eebcd0f0/crc-24-0508_f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc55/11758400/ffc640c45d74/crc-24-0508_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc55/11758400/2905bf357ea0/crc-24-0508_f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc55/11758400/aee8266ff0a3/crc-24-0508_f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc55/11758400/b3b3eebcd0f0/crc-24-0508_f4.jpg

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Non-invasive detection of lymphoma with circulating tumor DNA features and protein tumor markers.利用循环肿瘤DNA特征和蛋白质肿瘤标志物对淋巴瘤进行无创检测。
Front Oncol. 2024 Jan 19;14:1341997. doi: 10.3389/fonc.2024.1341997. eCollection 2024.
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Cancer statistics, 2024.2024年癌症统计数据。
CA Cancer J Clin. 2024 Jan-Feb;74(1):12-49. doi: 10.3322/caac.21820. Epub 2024 Jan 17.
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Circulating cell-free DNA fragmentation is a stepwise and conserved process linked to apoptosis.循环游离 DNA 片段化为凋亡相关的逐步且保守的过程。
BMC Biol. 2023 Nov 13;21(1):253. doi: 10.1186/s12915-023-01752-6.
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Blood-based tests for multicancer early detection (PATHFINDER): a prospective cohort study.基于血液的多种癌症早期检测（PATHFINDER）：一项前瞻性队列研究。
Lancet. 2023 Oct 7;402(10409):1251-1260. doi: 10.1016/S0140-6736(23)01700-2.
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