Gonzalez-Burgos Guillermo, Miyamae Takeaki, Nishihata Yosuke, Krimer Olga L, Wade Kirsten, Fish Kenneth N, Arion Dominique, Cai Zhao-Lin, Xue Mingshan, Stauffer William R, Lewis David A
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Department of Neuroscience, Baylor College of Medicine, Houston, Texas, United States.
J Neurophysiol. 2025 Feb 1;133(2):399-413. doi: 10.1152/jn.00326.2024. Epub 2024 Dec 31.
The primate dorsolateral prefrontal cortex (DLPFC) displays unique in vivo activity patterns, but how in vivo activity regulates DLPFC pyramidal neuron (PN) properties remains unclear. We assessed the effects of in vivo Kir2.1 overexpression, a genetic silencing tool, on synapses in monkey DLPFC PNs. We show for the first time that recombinant ion channel expression successfully modifies the excitability of primate cortex neurons, producing effects on synaptic properties apparently different from those in the rodent cortex.
灵长类动物的背外侧前额叶皮质（DLPFC）表现出独特的体内活动模式，但体内活动如何调节DLPFC锥体神经元（PN）的特性仍不清楚。我们评估了一种基因沉默工具——体内过表达Kir2.1对猴DLPFC锥体神经元突触的影响。我们首次表明，重组离子通道的表达成功改变了灵长类动物皮质神经元的兴奋性，对突触特性产生的影响明显不同于啮齿动物皮质。
