Lechien Jérôme R
Department of Surgery, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium; Division of Laryngology and Bronchoesophagology, Department of Otolaryngology Head Neck Surgery, EpiCURA Hospital, Baudour, Saint-Ghislain, Belgium; Department of Otolaryngology-Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France; Department of Otolaryngology, Elsan Hospital, Paris, France.
J Voice. 2024 Dec 30. doi: 10.1016/j.jvoice.2024.12.026.
To investigate the anxiety and depression features in laryngopharyngeal reflux disease (LPRD).
A laryngologist and librarian conducted a PubMed, Scopus, and Cochrane Library systematic review related to anxiety, depression, and mental health in LPRD through the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statements.
Of the 96 identified studies, 22 publications met the inclusion criteria, accounting for 2162 patients with suspected LPRD (n = 1607), gastroesophageal reflux disease (GERD; n = 423), both LPRD and GERD (n = 132), and 926 healthy/asymptomatic individuals. The LPRD diagnosis was mainly based on symptoms and findings. Twenty-six different mental health instruments were used across the studies. Anxiety was found in 28.8%-39.3% of patients with suspected LPRD. Depression was documented in 6.3%-45.6% of suspected LPRD. Most studies reported a significantly higher prevalence/incidence of anxiety and depression in suspected LPRD compared to controls. The LPRD symptom severity was associated with the severity of anxiety and depression in all studies exploring association findings. The anxiety and depression symptoms were reported as higher in LPRD compared to GERD populations. The bias analysis highlighted an important heterogeneity between studies, especially for the LPRD diagnosis and the mental health instruments used.
The prevalence of depression and anxiety is commonly higher in suspected LPRD compared to asymptomatic individuals. Future studies are needed to understand the association between the development of LPRD and mental health disorders.
探讨喉咽反流病（LPRD）患者的焦虑和抑郁特征。
一名喉科医生和一名图书馆员按照系统评价和Meta分析的首选报告项目声明，对PubMed、Scopus和Cochrane图书馆中有关LPRD患者焦虑、抑郁和心理健康的研究进行了系统评价。
在96项已识别的研究中，22篇文献符合纳入标准，涉及2162例疑似LPRD患者（n = 1607）、胃食管反流病（GERD；n = 423）、LPRD和GERD患者（n = 132）以及926名健康/无症状个体。LPRD的诊断主要基于症状和检查结果。各项研究共使用了26种不同的心理健康评估工具。在疑似LPRD患者中，焦虑发生率为28.8%-39.3%。抑郁发生率为6.3%-45.6%。大多数研究报告称，与对照组相比，疑似LPRD患者的焦虑和抑郁患病率/发病率显著更高。在所有探索相关性的研究中，LPRD症状严重程度与焦虑和抑郁严重程度相关。据报告，LPRD患者的焦虑和抑郁症状高于GERD患者。偏倚分析突出了各项研究之间存在的重要异质性，尤其是在LPRD诊断和所使用的心理健康评估工具方面。
与无症状个体相比，疑似LPRD患者中抑郁和焦虑的患病率通常更高。未来需要开展研究，以了解LPRD的发生与精神障碍之间的关联。
