强吸收分子使组织变得透明：理解组织光学透明化的新见解。

Strongly absorbing molecules make tissue transparent: a new insight for understanding tissue optical clearing.

作者信息

Yu Tingting, Zhu Dan

机构信息

Britton Chance Center for Biomedical Photonics-MoE Key Laboratory for Biomedical Photonics, Advanced Biomedical Imaging Facility-Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China.

出版信息

Light Sci Appl. 2025 Jan 1;14(1):10. doi: 10.1038/s41377-024-01675-z.

DOI:10.1038/s41377-024-01675-z

PMID:39741136

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11688419/

Abstract

Optical imaging plays a central role in the field of biomedicine, but it suffers from the light scattering of tissues. The research group from Stanford University has reported a counterintuitive observation that strongly absorbing molecules could achieve optical transparency in live animals, providing a new insight for understanding tissue optical clearing. It empowers scientists to leverage optical imaging techniques for in vivo observation of a wide range of deep-seated structures and activities.

摘要

光学成像在生物医学领域发挥着核心作用，但它受到组织光散射的困扰。斯坦福大学的研究小组报告了一个违反直觉的观察结果，即强吸收分子在活体动物中可以实现光学透明，这为理解组织光学透明化提供了新的见解。它使科学家能够利用光学成像技术对各种深层结构和活动进行体内观察。