Song Wanyu, Chen Xiuli, Wu Haiying, Rahimian Neda
Department of Obstetrics, Henan Provincial People's Hospital, Zhengzhou, 450003, Henan, China.
People's Hospital of Zhengzhou University, Zhengzhou, 450003, Henan, China.
Eur J Med Res. 2024 Dec 31;29(1):643. doi: 10.1186/s40001-024-02230-7.
Infertility is a prevalent problem among 10% of people within their reproductive years. Sometimes, even advanced treatment options like assisted reproduction technology have the potential to result in failed implantation. Because of the expected changes in gene expression during both in vitro and in vivo fertilization processes, these methods of assisting fertility have also been associated with undesirable pregnancy outcomes related to infertility. In this aspect, Circular RNAs (circRNAs) play a crucial role as epigenetic modifiers in a wide range of biological and pathological activities, including problems with fertility. CircRNAs are integral pieces in multiple cellular functions, including moving substances within the nucleus, silencing one X chromosome, cell death, the ability of stem cells to differentiate into different cell types, and the process of gene expression inherited from parental genes. Due to the progress made in high-speed gene sequencing, a large amount of circRNA molecules have been detected, revealing their significant functions in diverse biological functions like enhancing testicular development, preserving the differentiation and renewal of spermatogonial cells, and controlling spermatocyte meiosis. Moreover, these non-coding RNAs contribute in different aspects of female reproductive system including pregnancy-related diseases, gynecologic cancers, and endometriosis. In conclusion, there is no denying that circRNAs have immense potential to be used as biomarkers and treatments for reproductive disorders in males and females. In this research, we provide a comprehensive analysis of the multiple circRNAs associated with women's infertility.
不孕不育是10%处于生育年龄人群中的普遍问题。有时，即使是辅助生殖技术等先进的治疗方案也有可能导致着床失败。由于体外受精和体内受精过程中基因表达会发生预期变化，这些辅助生育方法也与不孕不育相关的不良妊娠结局有关。在这方面，环状RNA（circRNA）作为表观遗传修饰因子，在包括生育问题在内的广泛生物学和病理活动中发挥着关键作用。CircRNA是多种细胞功能的重要组成部分，包括细胞核内物质运输、一条X染色体失活、细胞死亡、干细胞分化为不同细胞类型的能力以及从亲代基因遗传的基因表达过程。由于高速基因测序技术的进步，已检测到大量circRNA分子，揭示了它们在多种生物学功能中的重要作用，如促进睾丸发育、维持精原细胞的分化和更新以及控制精母细胞减数分裂。此外，这些非编码RNA在女性生殖系统的不同方面发挥作用，包括妊娠相关疾病、妇科癌症和子宫内膜异位症。总之，不可否认circRNA具有巨大潜力，可作为男性和女性生殖障碍的生物标志物和治疗手段。在本研究中，我们对与女性不孕不育相关的多种circRNA进行了全面分析。
