Li Peipei, Liu Jiaqi, Yang Jianying, He Jie, Jiang Jiaqing
School of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan, China.
Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China.
Front Neurol. 2024 Dec 17;15:1444470. doi: 10.3389/fneur.2024.1444470. eCollection 2024.
Obstructive sleep apnea-hypopnea syndrome is the most common respiratory disorder in patients with multiple sclerosis. The purpose of this meta-analysis was to evaluate the prevalence of OSAHS in MS patients and to analyze their sleep monitoring indicators of patients.
Online databases such as PubMed, EMBASE, Web of Science, CNKI, and WanFang were used to review the Chinese and English literature about OSAHS in MS patients in detail. Two researchers analyzed the Quality of included studies based on the Quality Assessment of Diagnostic Accuracy Studies. The prevalence and sleep monitoring data were analyzed using STATA 11.0 software. Based on the I values, pooled analyses were performed using either random (I > 50%) or fixed-effect models (I ≤ 50%).
Fourteen articles were selected for the final analysis. Our study shows that different diagnosis methods of OSAHS lead to different incidences. When the screening method was PSG, the incidence of OSAHS in MS patients was 36%; when the method was STOP-BANG, the incidence of OSAHS in MS patients was 26%; when the method was Berlin questionnaire, the incidence of OSAHS in MS patients was 30%. We performed subgroup analyses based on race, age, OSAHS severity, and BMI of patients with MS. The results suggested that the incidence of OSAHS was different in different subgroups of MS patients. In addition, we found that patients with MS generally had poorer sleep monitoring indicators.
The current literature shows that the incidence of OSAHS is higher in MS patients. MS may affect the progression of OSAHS.
https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=551500, CRD42024551500.
阻塞性睡眠呼吸暂停低通气综合征是多发性硬化症患者中最常见的呼吸系统疾病。本荟萃分析的目的是评估多发性硬化症患者中阻塞性睡眠呼吸暂停低通气综合征（OSAHS）的患病率，并分析患者的睡眠监测指标。
使用PubMed、EMBASE、Web of Science、中国知网和万方等在线数据库，详细检索有关多发性硬化症患者中OSAHS的中英文文献。两名研究人员根据诊断准确性研究的质量评估对纳入研究的质量进行分析。使用STATA 11.0软件分析患病率和睡眠监测数据。根据I值，使用随机效应模型（I>50%）或固定效应模型（I≤50%）进行汇总分析。
最终纳入14篇文章进行分析。我们的研究表明，OSAHS的不同诊断方法导致不同的发病率。当筛查方法为多导睡眠图（PSG）时，多发性硬化症患者中OSAHS的发病率为36%；当方法为STOP-BANG问卷时，多发性硬化症患者中OSAHS的发病率为26%；当方法为柏林问卷时，多发性硬化症患者中OSAHS的发病率为30%。我们根据多发性硬化症患者的种族、年龄、OSAHS严重程度和体重指数进行了亚组分析。结果表明，多发性硬化症患者不同亚组中OSAHS的发病率不同。此外，我们发现多发性硬化症患者的睡眠监测指标普遍较差。
当前文献表明，多发性硬化症患者中OSAHS的发病率较高。多发性硬化症可能影响OSAHS的进展。
https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=551500，CRD42024551500 。
