新冠病毒感染患者复杂分离株中高毒力与多重耐药性的趋同
Convergence of Hypervirulence and Multidrug-Resistance in Complex Isolates from Patients with COVID-19.
作者信息
Du Mengjiao, Chi Cheng, Xiong LuYing, Rong Jincheng, Yi Maoli, Zhao Qi, Chi Xiaohui
机构信息
Department of Medical Laboratory, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, People's Republic of China.
State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
出版信息
Infect Drug Resist. 2024 Dec 27;17:5855-5866. doi: 10.2147/IDR.S495676. eCollection 2024.
PURPOSE
is a conditioned pathogen in the medical setting and mainly affects patients with cystic fibrosis. We found co-infection with complex (Bcc) in many patients with respiratory tract infections, including H7N9 and COVID-19. However, previous studies have not focused on co-infections with BCC and respiratory viruses. Therefore, this study attempted to clarify the evolution of COVID-19-Bcc and H7N9-Bcc in terms of genetic background, antibiotic resistance, and virulence phenotypes.
METHODS
This study retrospectively collected 49 Bcc isolated from patients with H7N9 and COVID-19 in a tertiary hospital of Zhejiang Province, of which 42 isolates were isolated from patients with H7N9, seven isolates were isolated from patients with COVID-19. The collected isolates were tested for antibiotic susceptibility, infection model, and whole-genome COVID-19-Bcc Characterization.
RESULTS
The test results of 49 strains of Bcc showed that the strains isolated from COVID-19 patients accounted for 57.1% of multidrug-resistance resistant strains. Statistical analysis of the median lethal time of showed that the median fatal time for COVID-19-Bcc was shorter and more virulent than that of H7N9-Bcc (P<0.05). The results of phylogenetic analysis indicated that COVID-19-Bcc may have evolved from H7N9-Bcc.
CONCLUSION
In this study, co-infection with BCC in many patients with respiratory tract infections, including H7N9 and COVID-19, was first identified and clarified that COVID-19-Bcc may have evolved from H7N9-Bcc and has the characteristics of hypervirulence and multidrug resistance.
目的
是医疗环境中的一种条件性病原体，主要影响囊性纤维化患者。我们在包括H7N9和COVID-19在内的许多呼吸道感染患者中发现了与复杂菌（Bcc）的合并感染。然而，先前的研究并未关注BCC与呼吸道病毒的合并感染。因此，本研究试图从遗传背景、抗生素耐药性和毒力表型方面阐明COVID-19 - Bcc和H7N9 - Bcc的演变情况。
方法
本研究回顾性收集了浙江省一家三级医院从H7N9和COVID-19患者中分离出的49株Bcc，其中42株分离自H7N9患者，7株分离自COVID-19患者。对收集到的分离株进行抗生素敏感性测试、感染模型和全基因组COVID-19 - Bcc特征分析。
结果
49株Bcc的检测结果显示，从COVID-19患者中分离出的菌株占多重耐药菌株的57.1%。对[具体内容未明确]的中位致死时间进行统计分析表明，COVID-19 - Bcc的中位致死时间比H7N9 - Bcc短且毒力更强（P<0.05）。系统发育分析结果表明，COVID-19 - Bcc可能由H7N9 - Bcc进化而来。
结论
在本研究中，首次鉴定出包括H7N9和COVID-19在内的许多呼吸道感染患者中存在与BCC的合并感染，并阐明COVID-19 - Bcc可能由H7N9 - Bcc进化而来，具有高毒力和多重耐药的特征。
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