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生物气溶胶的非致癌健康风险评估

Non-carcinogenic health risks assessment of bioaerosols.

作者信息

Siddique Azhar, Rasool Kashif

机构信息

Qatar Environment and Energy Research Institue (QEERI), Hamad Bin Khalifa University, Doha, Qatar.

出版信息

MethodsX. 2024 Dec 9;14:103088. doi: 10.1016/j.mex.2024.103088. eCollection 2025 Jun.

Abstract

Bioaerosols, pose potential health risks, yet quantitative assessments of non-carcinogenic risks from bioaerosol inhalation are limited. This study introduces a novel approach for assessing non-carcinogenic health risks using bioaerosol exposure data. The method employs the Average Daily Dose and Hazard Quotient (HQ) metrics, adapted from US Environmental Protection Agency guidelines, with the Reference Dose (RfD) based on thresholds from the National Institute of Occupational Safety and Health and the American Conference of Governmental Industrial Hygienists. This study utilizes a time-weighted approach, considering age-specific inhalation rates and body weights, to enhance the precision of lifetime exposure assessments. This methodology was applied to data collected over one year across multiple locations in Qatar, assessing seasonal and site-specific variations in risk. Results indicate generally low health risks, with HQ values below 1 for most sites and seasons. However, the study identified elevated HQ values at highly active sites during the dry summer, suggesting potential health concerns that need urgent attention. The proposed framework offers a replicable approach for evaluating bioaerosol-related health risks across diverse environments.•Novel adaptation of HQ-based risk assessment for bioaerosols in Qatar, incorporating a time-weighted approach.•Evaluation of seasonal and site-specific exposure dynamics.•Designed for replicability in different environmental conditions.

摘要

生物气溶胶会带来潜在的健康风险,然而,对吸入生物气溶胶所致非致癌风险的定量评估却很有限。本研究引入了一种利用生物气溶胶暴露数据评估非致癌健康风险的新方法。该方法采用了根据美国环境保护局指南改编的平均每日剂量和危害商数(HQ)指标,参考剂量(RfD)基于美国国家职业安全与健康研究所和美国政府工业卫生学家会议的阈值。本研究采用时间加权方法,考虑特定年龄的吸入率和体重,以提高终生暴露评估的精度。该方法应用于卡塔尔多个地点一年多来收集的数据,评估风险的季节性和特定地点差异。结果表明,总体健康风险较低,大多数地点和季节的HQ值低于1。然而,该研究发现,在干燥的夏季,高活动场所的HQ值升高,这表明存在需要紧急关注的潜在健康问题。所提出的框架为评估不同环境中与生物气溶胶相关的健康风险提供了一种可重复的方法。•在卡塔尔对基于HQ的生物气溶胶风险评估进行了新的改编,纳入了时间加权方法。•评估季节性和特定地点的暴露动态。•设计用于在不同环境条件下进行复制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2ee/11683212/5003936c8657/ga1.jpg

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