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酷似肌萎缩侧索硬化症的特发性多发性局限性脂肪萎缩

Idiopathic Multiple Localized Lipoatrophy Mimicking Amyotrophic Lateral Sclerosis.

作者信息

Mashimo Shuhei, Matsuoka Ayano, Tanese Keiji, Kano Osamu, Ishiko Akira

机构信息

Department of Dermatology, Toho University School of Medicine, Tokyo, JPN.

Department of Neurology, Toho University School of Medicine, Tokyo, JPN.

出版信息

Cureus. 2024 Dec 1;16(12):e74887. doi: 10.7759/cureus.74887. eCollection 2024 Dec.

DOI:10.7759/cureus.74887
PMID:39742161
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11686273/
Abstract

Localized lipoatrophy is a rare condition characterized by the localized loss of subcutaneous adipose tissue. It may occur idiopathically without specific triggers. The pathogenesis of idiopathic localized lipoatrophy remains largely unknown. We present the case of a 53-year-old Japanese woman with multiple localized lipoatrophy who exhibited upper motor neuron signs clinically and panniculitis histologically. She was initially suspected to have amyotrophic lateral sclerosis due to progressive left limb volume loss. Histologically, the lesions showed adipocyte destruction accompanied by predominant plasma infiltration.

摘要

局限性脂肪萎缩是一种罕见病症，其特征为皮下脂肪组织局限性缺失。它可能无特定诱因自发出现。特发性局限性脂肪萎缩的发病机制在很大程度上仍不清楚。我们报告一例53岁日本女性患有多处局限性脂肪萎缩的病例，该患者临床上表现为上运动神经元体征，组织学上表现为脂膜炎。她最初因左侧肢体渐进性体积减小而被怀疑患有肌萎缩侧索硬化症。组织学检查显示，病变表现为脂肪细胞破坏并伴有大量血浆浸润。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db0d/11686273/0b87fb187a69/cureus-0016-00000074887-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db0d/11686273/6a0ff940b512/cureus-0016-00000074887-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db0d/11686273/15b97a4607fb/cureus-0016-00000074887-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db0d/11686273/fc19d3c6d33c/cureus-0016-00000074887-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db0d/11686273/4420f07ba7b2/cureus-0016-00000074887-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db0d/11686273/0b87fb187a69/cureus-0016-00000074887-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db0d/11686273/6a0ff940b512/cureus-0016-00000074887-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db0d/11686273/15b97a4607fb/cureus-0016-00000074887-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db0d/11686273/fc19d3c6d33c/cureus-0016-00000074887-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db0d/11686273/4420f07ba7b2/cureus-0016-00000074887-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db0d/11686273/0b87fb187a69/cureus-0016-00000074887-i05.jpg

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