Chen Dan, Chen Jiaming, Dong Zemin, Cao Qingyun, Ye Hui, Feng Dingyuan, Zhang Changming, Zuo Jianjun, Wang Weiwei
Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.
Research Institute of Wens Foodstuff Group, Yunfu, China.
Vet Q. 2025 Dec;45(1):1-9. doi: 10.1080/01652176.2024.2447592. Epub 2025 Jan 1.
Weaning stress-induced diarrhea is a serious issue in pig production. This study aimed to evaluate the potential of glucose oxidase (GOD) as an antibiotic substitute to alleviate diarrhea and improve gut health in weaned piglets. According to a randomized complete block design, 250 piglets weaned around 21 d of age were allocated into 5 groups (5 replicates/group), which received a basal diet without or with supplemental 200 mg/kg antibiotic, 500, 1000 and 2000 U/kg GOD, respectively. Dietary treatments did not affect ( > 0.05) growth performance of piglets. However, supplemental all doses of GOD were equivalent or superior to antibiotic to reduce ( < 0.05) diarrhea as well as increase ( < 0.05) thymus index, hepatic and colonic antioxidant properties. GOD addition at 1000 and 2000 U/kg reduced ( < 0.05) cecal and rectal pH value, respectively. They also displayed similar or superior efficacy to antibiotic in improving ( < 0.05) duodenal and jejunal morphology along with certain tight junction proteins expression of jejunum and colon. Collectively, GOD represents an antibiotic alternative to reduce diarrhea of weaned piglets through associating with ameliorations of intestinal structure and functions.
断奶应激性腹泻是养猪生产中的一个严重问题。本研究旨在评估葡萄糖氧化酶（GOD）作为抗生素替代品在减轻断奶仔猪腹泻和改善肠道健康方面的潜力。根据随机完全区组设计，将250头约21日龄断奶的仔猪分为5组（每组5个重复），分别给予不添加或添加200 mg/kg抗生素、500、1000和2000 U/kg GOD的基础日粮。日粮处理对仔猪生长性能无影响（P＞0.05）。然而，所有剂量的GOD在减少腹泻（P＜0.05）以及提高胸腺指数、肝脏和结肠抗氧化性能方面与抗生素相当或更优。添加1000和2000 U/kg的GOD分别降低了盲肠和直肠pH值（P＜0.05）。在改善十二指肠和空肠形态以及空肠和结肠某些紧密连接蛋白表达方面，它们也表现出与抗生素相似或更优的效果（P＜0.05）。总体而言，GOD通过改善肠道结构和功能，可作为一种抗生素替代品来减少断奶仔猪的腹泻。
