Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 2, 10-719 Olsztyn, Poland.
Int J Environ Res Public Health. 2022 Jun 13;19(12):7246. doi: 10.3390/ijerph19127246.
Tetracyclines are a group of antibiotics whose first representative was discovered over 70 years ago. Since then, they have been of great interest in dermatology. In addition to their antibacterial activity, they are able to inhibit metalloproteinases and exhibit anti-inflammatory, anti-apoptotic and antioxidant effects. The side effects have been thoroughly studied over the years, the most characteristic and important ones in daily dermatological practice being: phototoxicity, hyperpigmentation, onycholysis, photoonycholysis, induced lupus erythematosus, and idiopathic intracranial hypertension. In this article, we summarize the use of tetracyclines in infectious diseases and inflammatory dermatoses, and further discuss the instances where the efficacy and safety of tetracyclines have been highlighted over the past few years.
四环素类是一组抗生素，其第一个代表药物是 70 多年前发现的。从那时起，它们就在皮肤科领域引起了极大的兴趣。除了具有抗菌活性外，它们还能够抑制金属蛋白酶，并具有抗炎、抗凋亡和抗氧化作用。多年来，其副作用已被彻底研究，在日常皮肤科实践中最具特征性和最重要的副作用是：光毒性、色素沉着过度、甲分离、光甲分离、诱导红斑狼疮和特发性颅内高压。本文总结了四环素在传染病和炎症性皮肤病中的应用，并进一步讨论了近年来四环素在疗效和安全性方面得到突出的情况。
