Zakrzewska Anna, Kosik-Kozioł Alicja, Zargarian Seyed Shahrooz, Zanoni Michele, Gualandi Chiara, Lanzi Massimiliano, Pierini Filippo
Department of Biosystems and Soft Matter, Institute of Fundamental Technological Research, Polish Academy of Sciences, Pawińskiego 5B, 02-106 Warsaw, Poland.
Department of Chemistry "Giacomo Ciamician″, University of Bologna, Via Selmi 2, 40126 Bologna, Italy.
Biomacromolecules. 2025 Jan 13;26(1):654-669. doi: 10.1021/acs.biomac.4c01466. Epub 2025 Jan 1.
Cross-linking bonds adjacent polymer chains into a three-dimensional network. Cross-linked poly(vinyl alcohol) (PVA) turns into a hydrogel, insoluble structure exhibiting outstanding sorption properties. As an electrospinnable polymer, PVA enables the creation of nanofibrous hydrogels resembling biological tissues, thus ideal for nature-inspired platforms. PVA properties are easily adjustable through additives and an appropriate cross-linking method. Drawing inspiration from environmentally safe approaches, this work developed a new "green" method of low-temperature PVA cross-linking. Nanofibers were electrospun from a precursor solution of PVA dissolved in fresh lemon juice, stabilized by heating at 60 °C for 7 days, and thoroughly characterized. The obtained nanoplatform demonstrated long-term stability and enhanced mechanical properties. Its biocompatibility was confirmed, and its antibacterial and health-promoting effects were attributed to lemon juice-rich in vitamin C, a potent antioxidant with anti-inflammatory properties. The developed system has future potential for use in the biomedical engineering field as a dressing accelerating wound healing.
交联键将相邻的聚合物链连接成三维网络。交联聚乙烯醇（PVA）转变为水凝胶，即一种具有出色吸附性能的不溶性结构。作为一种可静电纺丝的聚合物，PVA能够制备出类似生物组织的纳米纤维水凝胶，因此是自然启发型平台的理想选择。通过添加剂和适当的交联方法，PVA的性能易于调节。借鉴环境安全方法，本研究开发了一种新的低温PVA交联“绿色”方法。纳米纤维由溶解在新鲜柠檬汁中的PVA前驱体溶液静电纺丝而成，通过在60°C下加热7天进行稳定化处理，并进行了全面表征。所获得的纳米平台表现出长期稳定性和增强的机械性能。其生物相容性得到证实，其抗菌和促进健康的作用归因于富含维生素C的柠檬汁，维生素C是一种具有抗炎特性的强效抗氧化剂。所开发的系统在生物医学工程领域作为加速伤口愈合的敷料具有未来应用潜力。
