对接受血液透析的慢性肾病五期患者使用虚拟现实进行体育锻炼后PCSK9和TNF-α浓度变化的分析。

Analysis of changes in PCSK9 and TNF-α concentrations in response to physical exercises using virtual reality in patients in the fifth stage of chronic kidney disease undergoing hemodialysis.

作者信息

Turoń-Skrzypińska Agnieszka, Mińko Alicja, Rył Aleksandra, Cymbaluk-Płoska Aneta, Domański Maciej, Ciechanowski Kazimierz, Rotter Iwona

机构信息

Department of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University, Żołnierska 54, Szczecin, 71-210, Poland.

Department of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University, Powstańców Wielkopolskich 72, Szczecin, 70- 111, Poland.

出版信息

BMC Nephrol. 2025 Jan 2;26(1):1. doi: 10.1186/s12882-024-03917-z.

DOI:10.1186/s12882-024-03917-z

PMID:39743553

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11694471/

Abstract

BACKGROUND

The problem of reduced physical activity in patients with stage 5 Chronic Kidney Disease (CKD) is becoming more and more interesting in the medical community. One of the innovative solutions that can significantly increase patients' motivation to exercise is the integration of physical training with virtual reality (VR) technology during hemodialysis. The aim of this study was to comprehensively assess the impact of regular physical activity using virtual reality on the concentration of plasma PCSK9 protein and TNF-α in patients with stage 5 CKD treated with hemodialysis.

METHODS

A prototype of the NefroVR system was used in the research project. The study group consisted of patients who were entrusted with the task of conducting training using the prototype of the NefroVR system.

RESULTS

In the conducted research, a significant decrease in PCSK9 protein and TNF-α concentration was observed in the study group after 3 months of exercises using virtual reality in hemodialysis patients.

CONCLUSION

Regular physical activity using innovative physiotherapy methods, such as virtual reality, contributes to the improvement of inflammatory parameters and may improve lipid homeostasis.

CLINICAL TRIAL NUMBER

not applicable.

摘要

背景

终末期慢性肾脏病（CKD）患者身体活动减少的问题在医学界越来越受到关注。在血液透析期间将体育锻炼与虚拟现实（VR）技术相结合，是一种能够显著提高患者运动积极性的创新解决方案。本研究旨在全面评估使用虚拟现实进行规律体育活动对接受血液透析治疗的终末期CKD患者血浆前蛋白转化酶枯草溶菌素9（PCSK9）蛋白浓度和肿瘤坏死因子-α（TNF-α）的影响。