Turoń-Skrzypińska Agnieszka, Rotter Iwona, Przybyciński Jarosław, Szylińska Aleksandra, Mińko Alicja, Ciechanowski Kazimierz, Dutkiewicz Grażyna
Department and Unit of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University, 71-210 Szczecin, Poland.
Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, 70-111 Szczecin, Poland.
J Clin Med. 2023 Aug 17;12(16):5358. doi: 10.3390/jcm12165358.
Cytokines are a group of fine proteins which play a key role in the regulation of various biological processes, including inflammatory reactions. Proinflammatory cytokines, such as interleukin 1β (IL-1β), interleukin 6 (IL-6), and interleukin 8 (IL-8), are produced in response to various stimuli, including infections, tissue damage, and oxidative stress. Virtual reality (VR) use during intradialytic exercises improves physical activity. The purpose of the study was to evaluate the relationship between exercising regularly with the use of virtual reality during haemodialysis and the levels of selected cytokines (Il-1, Il-6, Il-8). The study and the control groups consisted of end-stage renal disease patients who underwent haemodialysis as a renal replacement treatment. The study group comprised patients subject to haemodialysis as a renal replacement therapy who were to work out with the use of a prototype of the NefroVR system for 20 min when undergoing haemodialysis (HD). Statistical analyses utilised Statistica 13. The conducted research demonstrated that regular exercises with the use of virtual reality might be related to a decrease in inflammation in patients included in the chronic haemodialysis programme. It is key to encourage patients with end-stage renal disease treated with haemodialysis to exercise regularly because of the possibility of their proinflammatory parameters becoming reduced.
细胞因子是一类精细的蛋白质，在包括炎症反应在内的各种生物过程的调节中起关键作用。促炎细胞因子，如白细胞介素1β（IL-1β）、白细胞介素6（IL-6）和白细胞介素8（IL-8），是在对包括感染、组织损伤和氧化应激在内的各种刺激作出反应时产生的。透析期间进行虚拟现实（VR）锻炼可改善身体活动。本研究的目的是评估血液透析期间定期使用虚拟现实进行锻炼与所选细胞因子（Il-1、Il-6、Il-8）水平之间的关系。研究组和对照组由接受血液透析作为肾脏替代治疗的终末期肾病患者组成。研究组包括接受血液透析作为肾脏替代疗法的患者，他们在进行血液透析（HD）时使用NefroVR系统原型锻炼20分钟。统计分析使用Statistica 13。所进行的研究表明，在慢性血液透析项目中，定期使用虚拟现实进行锻炼可能与患者炎症的减轻有关。鼓励接受血液透析治疗的终末期肾病患者定期锻炼很关键，因为这有可能降低他们的促炎参数。
