Bai Long, Li Jilong, Li Guangfeng, Zhou Dongyang, Su Jiacan, Liu Changsheng
Organoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai, China.
National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai, China.
Bone Res. 2025 Jan 2;13(1):1. doi: 10.1038/s41413-024-00378-w.
Accumulating research has shed light on the significance of skeletal interoception, in maintaining physiological and metabolic homeostasis related to bone health. This review provides a comprehensive analysis of how skeletal interoception influences bone homeostasis, delving into the complex interplay between the nervous system and skeletal system. One key focus of the review is the role of various factors such as prostaglandin E2 (PGE2) in skeletal health via skeletal interoception. It explores how nerves innervating the bone tissue communicate with the central nervous system to regulate bone remodeling, a process critical for maintaining bone strength and integrity. Additionally, the review highlights the advancements in biomaterials designed to utilize skeletal interoception for enhancing bone regeneration and treatment of bone disorders. These biomaterials, tailored to interact with the body's interoceptive pathways, are positioned at the forefront of innovative treatments for conditions like osteoporosis and fractures. They represent a convergence of bioengineering, neuroscience, and orthopedics, aiming to create more efficient and targeted therapies for bone-related disorders. In conclusion, the review underscores the importance of skeletal interoception in physiological regulation and its potential in developing more effective therapies for bone regeneration. It emphasizes the need for further research to fully understand the mechanisms of skeletal interoception and to harness its therapeutic potential fully.
越来越多的研究揭示了骨骼内感受在维持与骨骼健康相关的生理和代谢稳态方面的重要性。本综述全面分析了骨骼内感受如何影响骨骼稳态，深入探讨了神经系统与骨骼系统之间复杂的相互作用。该综述的一个关键重点是各种因素，如前列腺素E2（PGE2）通过骨骼内感受在骨骼健康中的作用。它探讨了支配骨组织的神经如何与中枢神经系统通信以调节骨重塑，这一过程对于维持骨骼强度和完整性至关重要。此外，该综述强调了旨在利用骨骼内感受来促进骨再生和治疗骨疾病的生物材料的进展。这些生物材料经过定制，可与人体的内感受途径相互作用，处于骨质疏松症和骨折等病症创新治疗的前沿。它们代表了生物工程、神经科学和骨科的融合，旨在为与骨骼相关的疾病创造更有效、更有针对性的治疗方法。总之，该综述强调了骨骼内感受在生理调节中的重要性及其在开发更有效的骨再生治疗方法方面的潜力。它强调需要进一步研究以充分了解骨骼内感受的机制并充分发挥其治疗潜力。
