耳蜗霉素H，一种从海绵衍生真菌sp. ZYX-Z-4中分离得到的新型12元间苯二酚酸内酯。

Cochliomycin H, a new 12-membered resorcylic acid lactone from sponge-derived fungus sp. ZYX-Z-4.

作者信息

Zhou Jiu-Jiu, Yang Li, Ma Qing-Yun, Xie Qing-Yi, Dai Hao-Fu, Liu You-Hua, You-Xing Zhao

机构信息

Zhejiang Guangsha Vocational and Technical University of Construction, Dongyang, China.

Haikou Key Laboratory for Research and Utilization of Tropical Natural Products & National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan, China.

出版信息

Nat Prod Res. 2025 Jan 1:1-5. doi: 10.1080/14786419.2024.2448206.

DOI:10.1080/14786419.2024.2448206

PMID:39743781

Abstract

A new 12-membered resorcylic acid lactone, cochliomycin H (), and one known resorcylic acid lactone, -demethylated-zeaenol (), were isolated from sponge-derived fungus sp. ZYX-Z-4. The structure of was elucidated by 1D and 2D NMR spectroscopic as well as HR-ESI-MS analysis. The configuration of was established by the NMR chemical shifts calculation followed by DP4+ analysis and ECD calculation. Compounds and were evaluated for the antifungal and neuroprotective activities and compound showed comparable neuroprotective effect on the HO injured SH-SY5Y cells to that of trolox.

摘要

从海绵来源的真菌ZYX-Z-4中分离出一种新的12元间苯二酚酸内酯，曲古抑菌素H（），以及一种已知的间苯二酚酸内酯，去甲基玉米烯醇（）。通过一维和二维核磁共振光谱以及高分辨电喷雾电离质谱分析阐明了的结构。通过核磁共振化学位移计算，随后进行DP4 +分析和电子圆二色计算确定了的构型。对化合物和进行了抗真菌和神经保护活性评估，化合物对HO损伤的SH-SY5Y细胞显示出与曲洛昔芬相当的神经保护作用。