Zhao Yiqiao, Chen Hao, Fu Jiahao, Wang Ao, Liu Xin, Jiang Xiaohong
Nanjing University of Science and Technology, 200, Xiaolingwei Street, Nanjing 210094, China.
Department of Orthopedics, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.
ACS Appl Bio Mater. 2025 Jan 20;8(1):285-298. doi: 10.1021/acsabm.4c01175. Epub 2025 Jan 1.
The resection of bone tumors results in large bone defects with some residual tumor cells, and the treatment of this type of bone defect area often faces a dilemma, namely, the trade-off between bone repair and antitumor after the resection of bone tumors. In order to promote local bone repair, and at the same time inhibit tumor recurrence by continuous and controlled drug administration, we developed a multifunctional NIR-responsive scaffold, whose main components are polylactic acid and MXene, and loaded with PLGA/DOX microspheres, and we hope that the scaffold can take into account both antitumor and bone repair in the bidirectional modulation effect of NIR. The results showed that the scaffold with 1% MXene content had relatively good performance in photothermal therapy (PT) and other aspects, and it could be smoothly increased to 50 °C within 2 min under NIR illumination, and the drug release of microspheres was increased by 10% after illumination compared with that at body temperature. In vivo experiments in animals showed that this scaffold effectively limited the in situ recurrence of tumor cells and lung metastasis and was able to promote osteogenic differentiation under NIR irradiation. Therefore, this scaffold can not only control the release of antitumor drugs but also enhance the antitumor effect through the bidirectional modulation effect of PT and at the same time promote bone formation, which provides a good application solution for the integrated treatment of the bone defect area after bone tumor surgery.
骨肿瘤切除会导致大的骨缺损并残留一些肿瘤细胞，这类骨缺损区域的治疗常常面临两难境地，即骨肿瘤切除后骨修复与抗肿瘤之间的权衡。为了促进局部骨修复，同时通过持续且可控的药物给药抑制肿瘤复发，我们研发了一种多功能近红外响应支架，其主要成分是聚乳酸和MXene，并负载了聚乳酸-羟基乙酸共聚物/阿霉素微球，我们希望该支架在近红外的双向调节作用中能兼顾抗肿瘤和骨修复。结果表明，MXene含量为1%的支架在光热治疗（PT）等方面具有相对良好的性能，在近红外光照下2分钟内可顺利升温至50°C，光照后微球的药物释放量相比体温时增加了10%。动物体内实验表明，这种支架有效限制了肿瘤细胞的原位复发和肺转移，并且在近红外照射下能够促进成骨分化。因此，这种支架不仅可以控制抗肿瘤药物的释放，还能通过PT的双向调节作用增强抗肿瘤效果，同时促进骨形成，为骨肿瘤手术后骨缺损区域的综合治疗提供了良好的应用解决方案。
