Egidi Sara, Valentini Valentino, Schiavetti Amalia
Private Practice, Rome, Italy.
Maxillofacial Surgery Department, Sapienza University, Rome, Italy.
Front Oncol. 2024 Dec 18;14:1501556. doi: 10.3389/fonc.2024.1501556. eCollection 2024.
Myoepithelial carcinoma is a very rare yet aggressive tumor in children. Surgical intervention and local radiotherapy often lead to post-therapy complications, affecting both the aesthetic and functional quality of life in survivors. Hyaluronic acid (HA) dermal fillers offer a minimally invasive option to improve the appearance and quality of life for these patients once they are declared tumor-free.
We present the case of an 18-year-old girl with a history of myoepithelial carcinoma in the right upper orbit, diagnosed at the age of 8. The patient underwent surgery to remove the tumor and lacrimal gland, followed by chemotherapy and radiotherapy. A complete response to treatment was achieved, and the patient was monitored with regular clinical and radiological exams for 5 years, after which she was declared tumor-free and followed for late effects of therapy. Post-surgical radiotherapy resulted in atrophy of the upper orbital frame and functional complications. The patient exhibited upper eyelid retraction, ptosis, continuous lacrimation, and conjunctival redness. Ten years after treatment, the patient underwent dermal filler injections using Aliaxin Essential Volume (A) and Aliaxin Superior Volume (A) to address the aesthetic impairment of the upper right orbit. A was administered using a 22G x 50mm cannula on the periosteum of the superior orbital frame, entering from the outer canthus. A was injected with a cannula into the muscle, also entering from the outer canthus. Before treatment, the patient exhibited upper eyelid retraction, ptosis, continuous lacrimation, and conjunctival redness. Following the injections, improvements were observed in all pre-treatment symptoms. The closing ability of the upper eyelid was restored, along with superior orbital volume and symmetry. Enhanced eyelid function improved eye hydration, reduced redness in the conjunctiva, and led to better vision and overall quality of life.
To our knowledge, this is the first reported case of using dermal fillers to treat ocular changes resulting from cancer treatment. Injections of A and A provided both aesthetic and functional improvements.
肌上皮癌是一种在儿童中非常罕见但具有侵袭性的肿瘤。手术干预和局部放疗常常导致治疗后并发症，影响幸存者的美观和生活功能质量。透明质酸（HA）真皮填充剂为这些患者在被宣布无肿瘤后改善外观和生活质量提供了一种微创选择。
我们报告一例18岁女孩，其右上眼眶有肌上皮癌病史，8岁时被诊断出。患者接受了肿瘤及泪腺切除手术，随后进行了化疗和放疗。治疗取得了完全缓解，患者接受了5年的定期临床和放射学检查监测，之后被宣布无肿瘤，并对治疗的晚期影响进行随访。手术后放疗导致上眼眶框架萎缩和功能并发症。患者出现上睑退缩、上睑下垂、持续性流泪和结膜充血。治疗十年后，患者使用Aliaxin Essential Volume（A）和Aliaxin Superior Volume（A）进行真皮填充剂注射，以解决右上眼眶的美观受损问题。A通过一根22G×50mm的套管从外眦进入，在上眼眶框架的骨膜上给药。A也通过一根套管从外眦进入，注入肌肉。治疗前，患者表现为上睑退缩、上睑下垂、持续性流泪和结膜充血。注射后，所有治疗前症状均有改善。上睑闭合能力得以恢复，上眼眶容积和对称性也得到改善。眼睑功能增强改善了眼部水合作用，减轻了结膜充血，并带来了更好的视力和整体生活质量。
据我们所知，这是首例报道使用真皮填充剂治疗癌症治疗引起的眼部改变的病例。注射A和A在美观和功能方面均有改善。
