Aparicio Andrea, Sun Zheng, Gold Diane R, Lasky-Su Jessica A, Litonjua Augusto A, Weiss Scott T, Lee-Sarwar Kathleen, Liu Yang-Yu
Department of Medicine, Brigham and Women's Hospital and Harvard Medical School Channing Division of Network Medicine Boston Massachusetts USA.
Department of Environmental Health Harvard T.H. Chan School of Public Health Boston Massachusetts USA.
mLife. 2024 Dec 24;3(4):573-577. doi: 10.1002/mlf2.12153. eCollection 2024 Dec.
Through the analysis of data from children aged 6 months to 8 years enrolled in the Vitamin D Antenatal Asthma Reduction Trial (VDAART), significant simultaneous associations were identified between variants in the fragile histidine triad () gene, children's body mass index, microbiome features related to obesity, and key lipids and amino acids. These patterns represent evidence of the genotype influence in shaping the host microbiome in developing stages and new potential biomarkers for childhood obesity, insulin resistance, and type 2 diabetes.
通过对参与维生素D产前哮喘减少试验（VDAART）的6个月至8岁儿童的数据进行分析，发现脆性组氨酸三联体（FHIT）基因变异、儿童体重指数、与肥胖相关的微生物组特征以及关键脂质和氨基酸之间存在显著的同时关联。这些模式代表了基因在发育阶段塑造宿主微生物组方面的影响证据，以及儿童肥胖、胰岛素抵抗和2型糖尿病的新潜在生物标志物。
