Jung Dong Won, Choi Ji Yun
Department of Otolaryngology-Head and Neck Surgery, Chosun University College of Medicine, Gwangju, Republic of Korea.
J Rhinol. 2024 Nov;31(3):179-183. doi: 10.18787/jr.2024.00025. Epub 2024 Nov 30.
IgG4-related disease (IgG4-RD) is a systemic inflammatory condition characterized by tissue infiltration with IgG4-positive plasma cells and a tendency to form mass-like lesions in various organs. IgG4-related sinusitis, although a relatively rare manifestation of IgG4-RD, significantly impacts the paranasal sinuses. A 52-year-old man presented with persistent rhinorrhea, nasal obstruction, and headaches. He was diagnosed with IgG4-RD involving the bilateral nasal cavity, paranasal sinuses, submandibular glands, lacrimal glands, and parotid glands. We recently managed a case of IgG4-related sinusitis, which was successfully diagnosed and treated. This condition represents a distinct subset of chronic rhinosinusitis, with unique pathophysiological and clinical features. Accurate diagnosis and effective management of IgG4-related sinusitis require a high index of suspicion and a multidisciplinary approach.
IgG4相关性疾病（IgG4-RD）是一种全身性炎症性疾病，其特征是IgG4阳性浆细胞浸润组织，并倾向于在各个器官形成肿块样病变。IgG4相关性鼻窦炎虽然是IgG4-RD相对罕见的表现，但对鼻窦有显著影响。一名52岁男性出现持续性鼻漏、鼻塞和头痛。他被诊断为IgG4-RD累及双侧鼻腔、鼻窦、下颌下腺、泪腺和腮腺。我们最近处理了一例IgG4相关性鼻窦炎病例，该病例得到了成功诊断和治疗。这种疾病代表了慢性鼻-鼻窦炎的一个独特亚组，具有独特的病理生理和临床特征。准确诊断和有效管理IgG4相关性鼻窦炎需要高度的怀疑指数和多学科方法。
