• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

1型晚发性发作性睡病中的猝倒状态伴快速眼动睡眠过多

Status Cataplecticus with Rapid Eye Movement Sleep Excess in Late-onset Narcolepsy Type 1.

作者信息

Ando Takashi, Wakai Masakazu, Kanbayashi Takashi, Katsuno Masahisa

机构信息

Department of Neurology, Nagoya University Graduate School of Medicine, Japan.

Department of Sleep Medicine, Chutoen General Medical Center, Japan.

出版信息

Intern Med. 2022 Oct 1;61(19):2951-2955. doi: 10.2169/internalmedicine.8465-21. Epub 2022 Mar 12.

DOI:10.2169/internalmedicine.8465-21
PMID:35283376
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9593136/
Abstract

A 57-year-old man presented with difficulty speaking and walking along with increased daytime somnolence. His symptoms fluctuated throughout the day but never completely disappeared. A neurological examination revealed mild dysarthria, limb weakness, and staggering gait. Polysomnography showed rapid eye movement (REM) sleep excess (55.0%). Multiple sleep latency tests revealed a mean sleep latency of zero minutes with sleep-onset REM periods in all naps. The Orexin-A concentration in the cerebrospinal fluid was low (50.8 pg/mL). Human leukocyte antigen testing demonstrated DQB1*0602 positivity. His neurological symptoms were relieved by clomipramine. Thus, he was diagnosed with late-onset narcolepsy type 1 with status cataplecticus.

摘要

一名57岁男性出现言语和行走困难，同时白天嗜睡加重。他的症状在一天中波动，但从未完全消失。神经系统检查发现轻度构音障碍、肢体无力和蹒跚步态。多导睡眠图显示快速眼动（REM）睡眠过多（55.0%）。多次睡眠潜伏期测试显示平均睡眠潜伏期为零分钟，所有小睡均出现睡眠起始REM期。脑脊液中食欲素-A浓度较低（50.8 pg/mL）。人类白细胞抗原检测显示DQB1*0602阳性。他的神经症状通过氯米帕明得到缓解。因此，他被诊断为伴有猝倒状态的晚发型1型发作性睡病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e758/9593136/52056383b0b7/1349-7235-61-2951-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e758/9593136/7d55f72011b9/1349-7235-61-2951-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e758/9593136/52056383b0b7/1349-7235-61-2951-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e758/9593136/7d55f72011b9/1349-7235-61-2951-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e758/9593136/52056383b0b7/1349-7235-61-2951-g002.jpg

相似文献

1
Status Cataplecticus with Rapid Eye Movement Sleep Excess in Late-onset Narcolepsy Type 1.1型晚发性发作性睡病中的猝倒状态伴快速眼动睡眠过多
Intern Med. 2022 Oct 1;61(19):2951-2955. doi: 10.2169/internalmedicine.8465-21. Epub 2022 Mar 12.
2
HLA haplotypes, polysomnography, and pedigrees in a case series of patients with narcolepsy.发作性睡病患者病例系列中的HLA单倍型、多导睡眠图和家系
Sleep. 1997 Oct;20(10):850-7. doi: 10.1093/sleep/20.10.850.
3
Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy.发作性睡病患者中无猝倒的下丘脑泌素（食欲素）缺乏的预测因子。
Sleep. 2012 Sep 1;35(9):1247-55F. doi: 10.5665/sleep.2080.
4
Nocturnal rapid eye movement sleep latency for identifying patients with narcolepsy/hypocretin deficiency.用于识别发作性睡病/下丘脑分泌素缺乏症患者的夜间快速眼动睡眠潜伏期。
JAMA Neurol. 2013 Jul;70(7):891-902. doi: 10.1001/jamaneurol.2013.1589.
5
Status cataplecticus as initial presentation of late onset narcolepsy.猝倒发作作为迟发性发作性嗜睡症的初始表现。
J Clin Sleep Med. 2014 Feb 15;10(2):207-9. doi: 10.5664/jcsm.3456.
6
REM behavior disorder (RBD) can be one of the first symptoms of childhood narcolepsy.快速眼动睡眠行为障碍（RBD）可能是儿童发作性睡病的首发症状之一。
Sleep Med. 2007 Nov;8(7-8):784-6. doi: 10.1016/j.sleep.2006.11.018. Epub 2007 Jun 13.
7
Status Cataplecticus Following Abrupt Withdrawal of Clomipramine.停用氯米帕明后出现猝倒状态。
Ir Med J. 2019 Sep 12;112(8):991.
8
Rare Case of Late-Onset Narcolepsy Type 1.1型发作性睡病迟发型罕见病例。
Case Rep Neurol. 2020 Nov 12;12(3):428-432. doi: 10.1159/000510633. eCollection 2020 Sep-Dec.
9
Narcolepsy without cataplexy: 2 subtypes based on CSF hypocretin-1/orexin-A findings.无猝倒发作的发作性睡病：基于脑脊液中食欲素-1/食欲肽-A检测结果的2种亚型
Sleep. 2006 Nov;29(11):1439-43. doi: 10.1093/sleep/29.11.1439.
10
The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias.脑脊液下丘脑分泌素测量在发作性睡病及其他发作性睡病的诊断中的作用。
Arch Neurol. 2002 Oct;59(10):1553-62. doi: 10.1001/archneur.59.10.1553.

引用本文的文献

1
Very late onset narcolepsy type 1: a case report and review of the literature.1型极晚发型发作性睡病：一例报告及文献综述
J Clin Sleep Med. 2025 May 1;21(5):917-929. doi: 10.5664/jcsm.11540.

本文引用的文献

1
Unexpected REM sleep excess associated with a pontine lesion in multiple sclerosis.多发性硬化症患者桥脑病变相关意外 REM 睡眠过多。
J Clin Sleep Med. 2021 May 1;17(5):1117-1119. doi: 10.5664/jcsm.9114.
2
Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment.发作性睡病-临床谱、病因病理生理学、诊断和治疗。
Nat Rev Neurol. 2019 Sep;15(9):519-539. doi: 10.1038/s41582-019-0226-9. Epub 2019 Jul 19.
3
International classification of sleep disorders-third edition: highlights and modifications.国际睡眠障碍分类第三版：要点和修改。
Chest. 2014 Nov;146(5):1387-1394. doi: 10.1378/chest.14-0970.
4
Status cataplecticus as initial presentation of late onset narcolepsy.猝倒发作作为迟发性发作性嗜睡症的初始表现。
J Clin Sleep Med. 2014 Feb 15;10(2):207-9. doi: 10.5664/jcsm.3456.
5
An interesting case of late age at onset of narcolepsy with cataplexy.一例有趣的迟发性发作伴猝倒的发作性睡病病例。
J Clin Sleep Med. 2014 Feb 15;10(2):203-5. doi: 10.5664/jcsm.3454.
6
The pathophysiologic basis of secondary narcolepsy and hypersomnia.继发性嗜睡症和过度睡眠的病理生理基础。
Curr Neurol Neurosci Rep. 2011 Apr;11(2):235-41. doi: 10.1007/s11910-011-0178-y.
7
The clinical features of cataplexy: a questionnaire study in narcolepsy patients with and without hypocretin-1 deficiency.猝倒症的临床特征：伴有和不伴有下丘脑分泌素-1 缺乏的发作性睡病患者的问卷调查研究。
Sleep Med. 2011 Jan;12(1):12-8. doi: 10.1016/j.sleep.2010.05.010. Epub 2010 Dec 8.
8
A sleepy patient with REM rebound.一名出现快速眼动睡眠反跳的嗜睡患者。
J Clin Sleep Med. 2009 Aug 15;5(4):386-9.
9
Narcolepsy with long sleep time: a specific entity?睡眠时间长的发作性睡病：一种特定的疾病实体？
Sleep. 2009 Sep;32(9):1229-35. doi: 10.1093/sleep/32.9.1229.
10
Obstructive sleep apnea in narcolepsy.发作性睡病中的阻塞性睡眠呼吸暂停。
Sleep Med. 2010 Jan;11(1):93-5. doi: 10.1016/j.sleep.2009.02.009. Epub 2009 Aug 20.