Parambil Sudheesh Allikka, De Kumar Bony
Department of Molecular Cellular and Developmental Biology, Yale University, New Haven, CT, USA.
Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA.
Methods Mol Biol. 2025;2889:1-10. doi: 10.1007/978-1-0716-4322-8_1.
Hox genes are crucial in determining segmentation identity in developing embryos, which ultimately sets an anteroposterior body axis. Over a century of research has discovered the fundamentals of the Hox gene and protein function in animal development and diseases. However, there are still fundamental questions about the specificity of HOX function. This chapter discusses many unknowns about Hox genes and how modern technologies can overcome technical limitations. We have also addressed these questions to gain a better understanding of the roles of these genes.
同源框基因对于发育中的胚胎确定体节特征至关重要，这最终确定了前后体轴。一个多世纪的研究已经发现了同源框基因和蛋白质在动物发育及疾病中的功能基础。然而，关于同源异型盒（HOX）功能的特异性仍存在一些基本问题。本章讨论了许多关于同源框基因的未知之处，以及现代技术如何克服技术限制。我们也探讨了这些问题，以便更好地理解这些基因的作用。
