Zezulak K M, Green H
Mol Cell Biol. 1985 Feb;5(2):419-21. doi: 10.1128/mcb.5.2.419-421.1985.
During the differentiation of preadipose 3T3 cells into adipose cells, the mRNAs for three proteins increase strikingly in abundance. To determine the degree of cell-type specificity in the expression of these mRNAs, we estimated their abundances in several nonadipose tissues of the mouse. None of these mRNAs was strictly confined to adipocytes, but the ensemble of three mRNAs was rather specific to adipocytes. Insofar as is revealed by these three markers, the distinctive phenotype of adipocytes is the result of the enhanced expression of a number of genes, none of which is completely silent in all other cell types.
在前脂肪3T3细胞分化为脂肪细胞的过程中，三种蛋白质的mRNA丰度显著增加。为了确定这些mRNA表达中的细胞类型特异性程度，我们估计了它们在小鼠几种非脂肪组织中的丰度。这些mRNA没有一种严格局限于脂肪细胞，但这三种mRNA的组合对脂肪细胞具有相当的特异性。就这三种标志物所揭示的情况而言，脂肪细胞独特的表型是许多基因表达增强的结果，其中没有一个基因在所有其他细胞类型中完全沉默。
